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Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity

Authors Jin J, Zhang L, Shi M, Zhang Y, Wang Q

Received 16 February 2017

Accepted for publication 17 April 2017

Published 7 June 2017 Volume 2017:12 Pages 4209—4224

DOI https://doi.org/10.2147/IJN.S134843

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Jianfeng Jin,1,2 Li Zhang,3 Mengqi Shi,3 Yumei Zhang,3 Qintao Wang1

1State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi’an, 2Department of General Dentistry, Kunming Municipal Stomatology Hospital, Kunming, 3State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China

Abstract: Surface modification of titanium (Ti) implants are extensively studied in order to obtain prominent biocompatibility and antimicrobial activity, especially preventing implant-associated infection. In this study, Ti substrates surface were modified by graphene oxide (GO) thin film and silver (Ag) nanoparticles via electroplating and ultraviolet reduction methods so as to achieve this purpose. Microstructures, distribution, quantities and spectral peaks of GO and Ag loading on the Ti sheets surface were characterized. GO-Ag-Ti multiphase nanocomposite exhibited excellent antimicrobial ability and anti-adherence performance. Subsequently, morphology, membrane integrity, apoptosis and relative genes expression of bacteria incubated on the Ti samples surface were monitored to reveal the bactericidal mechanism. Additionally, the cytotoxicity of Ti substrates incorporating GO thin film and Ag nanoparticles were investigated. GO-Ag-Ti composite configuration that have outstanding antibacterial properties will provide the foundation to study bone integration in vitro and in vivo in the future.

Keywords: GO-Ag-Ti multiphase nanocomposite, microstructure and quantities, antibacterial activity, bactericidal mechanism, cytotoxicity

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