Thyroid dysfunction among type 2 diabetic female Egyptian subjects
Authors Elebrashy IN, El Meligi A, Rashed L, Salam RF, Youseef E, Fathy SA
Received 8 May 2016
Accepted for publication 14 September 2016
Published 21 November 2016 Volume 2016:12 Pages 1757—1762
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 3
Editor who approved publication: Professor Garry Walsh
Ibrahim N Elebrashy,1 Amr El Meligi,1 Laila Rashed,2 Randa F Salam,1 Elham Youssef,1 Shaimaa A Fathy1
1Department of Internal Medicine, Diabetes, and Endocrinology, 2Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Giza, Egypt
Purpose: High prevalence of thyroid disorders is more common in type 1 diabetes compared to type 2 diabetes, due to associated autoimmunity. Hypothyroidism is the most common disorder. The objective was to assess the prevalence of thyroid dysfunction among type 2 diabetic Egyptian females and to find the correlation between metabolic syndrome components and autoimmune thyroid dysfunction.
Materials and methods: The study included 62 type 2 diabetic Egyptian females and 27 sex- and age-matched controls. All patients in the study were subjected to anthropometric measures, including HbA1c, lipid profile, serum uric acid, thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-thyroid peroxidase (TPO), antithyroglobulin (anti-Tg), and thyroid ultrasound.
Results: Hypothyroidism was found in 45.2% of patients (5.49±3.37 µIU/mL) versus 11.1% of controls (1.79±1.21 µIU/mL) (P<0.001). Anti-TPO was found in 75.8% (347.15±244.87 IU/mL) of patients versus 7.4% (32.89±33.26 IU/mL) of controls (P<0.001). Anti-Tg was found in 61.3% (508.03±369.16 IU/mL) of patients versus 0 (51.26±35.53 IU/mL) controls (P<0.001). A significant positive correlation was found between TSH and antithyroid antibodies (anti-Tg, anti-TPO; P=0.002 and P=0.043, respectively) and between TSH and thyroid-gland volume (P=0.002) in diabetic patients. No correlation was found between any components of metabolic syndrome and thyroid antibodies in diabetic patients.
Conclusion: Autoimmune thyroid disease is more common in Egyptian women with type 2 diabetes than nondiabetic women, and thus points to a role of autoimmunity in the pathogenesis of type 2 diabetes.
Keywords: autoimmune thyroid dysfunction, TSH, anti-TPO, anti-Tg, T2 diabetes, metabolic syndrome
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]