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Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome

Authors Wang S, Tu J, Pan Y

Received 24 September 2019

Accepted for publication 18 November 2019

Published 29 November 2019 Volume 2019:12 Pages 2501—2506

DOI https://doi.org/10.2147/DMSO.S232343

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nicola Ludin

Peer reviewer comments 2

Editor who approved publication: Dr Juei-Tang Cheng


Saibin Wang,1 Junwei Tu,1 Yibin Pan2

1Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People’s Republic of China; 2Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People’s Republic of China

Correspondence: Junwei Tu
Department of Respiratory Medicine, Jinhua Municipal Central Hospital, No. 365, East Renmin Road, Jinhua, Zhejiang Province 321000, People’s Republic of China
Tel +86 579 82552278
Fax +86 579 82325006
Email junweiau@126.com
Yibin Pan
Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, No. 365, East Renmin Road, Jinhua, Zhejiang Province 321000, People’s Republic of China
Tel +86 579 82552926
Fax +86 579 82552927
Email 18851733351@163.com

Background: Previous studies have suggested that the non-high-density lipoprotein cholesterol (non-HDL-C) is strongly associated with metabolic syndrome (MetS); however, the explicit relationship between them has not yet been clarified. The aim of this study was to reveal the explicit association between the non-HDL-C with MetS.
Methods: The present study was based on a cross-sectional study, which was carried out in Spain. A total of 60,799 workers were recruited between 2012 and 2016. Anthropometric parameters and blood indices (lipid profile and fasting blood glucose) were collected. Participants were divided into the MetS group or the non-MetS group based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III. The relationship between serum non-HDL-C and the risk of MetS was evaluated using multivariate regression analysis, piece-wise linear regression analysis, smooth curve fitting and threshold saturation effect analysis after adjustment of potential confounders.
Results: The risk of developing MetS increased with increasing non-HDL-C level. However, this association was only presented in the range of the non-HDL-C concentrations from 118 mg/dl to 247 mg/dl after adjusting for potential confounders. When compared to lower non-HDL-C level (247 mg/dl) were related to higher incidence of MetS, with adjusted odds ratio (95% confidence interval) of 3.08 (2.77, 3.42) and 17.18 (14.29, 20.65), respectively (P for trend <0.05).
Conclusion: Higher serum non-HDL-C level was associated with increased MetS incidence; however, significant threshold saturation effects were observed when the non-HDL-C level 247 mg/dl.

Keywords: non-high-density lipoprotein cholesterol, metabolic syndrome, threshold effect, lipid

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