Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Thiazolidinediones are associated with a reduced risk of COPD exacerbations

Authors Rinne ST, Liu CF, Feemster LC, Collins BF, Bryson CL, O’Riordan TG, Au DH

Received 11 February 2015

Accepted for publication 20 April 2015

Published 10 August 2015 Volume 2015:10(1) Pages 1591—1597

DOI https://doi.org/10.2147/COPD.S82643

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Seppo T Rinne,1,2 Chuan-Fen Liu,3,4 Laura C Feemster,3,5 Bridget F Collins,3,5 Christopher L Bryson,3,6 Thomas G O’Riordan,7 David H Au3,4

1Department of Veterans Affairs, VA Connecticut Healthcare System, West Haven, 2Division of Pulmonary and Critical Care, Yale University, New Haven, CT, USA; 3VA Puget Sound Health Care System, Department of Veterans Affairs, 4Department of Health Services, University of Washington, 5Division of Pulmonary and Critical Care, University of Washington, 6Division of General Internal Medicine, University of Washington, 7Gilead Sciences, Inc., Seattle, WA, USA

Background: Thiazolidinediones (TZDs) are oral antihyperglycemic medications that are selective agonists to peroxisome proliferator-activated receptor gamma and have been shown to have potent anti-inflammatory effects in the lung.
Objective: The purpose of this study was to assess whether exposure to TZDs is associated with a decreased risk of chronic obstructive pulmonary disease (COPD) exacerbation.
Methods: A cohort study was performed by collecting data on all US veterans with diabetes and COPD who were prescribed oral antihyperglycemic medications during from period of October 1, 2005 to September 30, 2007. Patients who had two or more prescriptions for TZDs were compared with patients who had two or more prescriptions for an alternative oral antihyperglycemic medication. Multivariable negative binomial regression was performed with adjustment for potential confounding factors. The primary outcome was COPD exacerbations, including both inpatient and outpatient exacerbations.
Results: We identified 7,887 veterans who were exposed to TZD and 42,347 veterans who were exposed to non-TZD oral diabetes medications. COPD exacerbations occurred in 1,258 (16%) of the TZD group and 7,789 (18%) of the non-TZD group. In multivariable negative binomial regression, there was a significant reduction in the expected number of COPD exacerbations among patients who were exposed to TZDs with an incidence rate ratio of 0.86 (95% CI 0.81–0.92).
Conclusion: Exposure to TZDs was associated with a small but significant reduction in risk for COPD exacerbation among diabetic patients with COPD.

Keywords: peroxisome proliferator-activated receptors, glitazones, COPD exacerbation, inflammation, cohort study
 

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease

Perez T, Burgel PR, Paillasseur JL, Caillaud D, Deslée G, Chanez P, Roche N

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1663-1672

Published Date: 18 August 2015

Relationship between linear and nonlinear dynamics of heart rate and impairment of lung function in COPD patients

Mazzuco A, Medeiros WM, Sperling MP, Souza AS, Alencar MC, Arbex FF, Neder JA, Arena R, Borghi-Silva A

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1651-1661

Published Date: 17 August 2015

VitalQPlus: a potential screening tool for early diagnosis of COPD

Sui CF, Ming LC, Neoh CF, Ibrahim B

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1613-1622

Published Date: 11 August 2015

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

D’Urzo AD, Kerwin EM, Chapman KR, Decramer M, DiGiovanni R, D’Andrea P, Hu H, Goyal P, Altman P

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1599-1612

Published Date: 11 August 2015

Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients

Ferrari R, Caram LMO, Faganello MM, Sanchez FF, Tanni SE, Godoy I

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1553-1558

Published Date: 6 August 2015

Bronchoscopic lung volume reduction by endobronchial valve in advanced emphysema: the first Asian report

Park TS, Hong Y, Lee JS, Oh SY, Lee SM, Kim N, Seo JB, Oh YM, Lee SD, Lee SW

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1501-1511

Published Date: 29 July 2015

Underrecognized comorbidities of chronic obstructive pulmonary disease

Miłkowska-Dymanowska J, Białas AJ, Zalewska-Janowska A, Górski P, Piotrowski WJ

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1331-1341

Published Date: 15 July 2015

Pulmonary hemodynamic profile in chronic obstructive pulmonary disease

Portillo K, Torralba Y, Blanco I, Burgos F, Rodriguez-Roisin R, Rios J, Roca J, Barberà JA

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1313-1320

Published Date: 14 July 2015