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Therapy effects of gold nanorods on the CNE-1 nasopharyngeal carcinoma cell line

Authors Shao J, Tang J, Ji J, Zhou W

Received 4 August 2012

Accepted for publication 6 September 2012

Published 25 October 2012 Volume 2012:6 Pages 297—301


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Jinyan Shao,1 Jianguo Tang,1 Jian Ji,2 Wenbo Zhou2

1Department of Otolaryngology, Head and Neck Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 2Department of Polymer Science, Ministry of Education Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou, People's Republic of China

Abstract: The use of nanocarriers to deliver drugs to tumor tissue is one of the most important strategies in cancer therapeutics. Recently, gold nanorods (GNRs) have begun to be used in cancer therapy because of their unique properties. The purpose of this study was to show the potential that GNRs have against human nasopharyngeal carcinoma CNE-1 cells, using near-infrared (NIR) laser light. Transmission electron microscopic and ultraviolet-visible spectroscopic investigations confirmed the efficient uptake of the GNRs by CNE-1 and human rhinal epithelia cells. The in vitro NIR photothermal therapy for the CNE-1 and rhinal epithelia cells was designed in three groups: (1) control, (2) laser alone, and (3) GNRs with laser. Fluorescence microscopy images indicated that, at some GNR concentrations and some intensities of NIR laser, GNRs with laser therapy could induce cell death for CNE-1 cells while keeping the rhinal epithelia cells healthy. Therefore, the results of this study suggest that using GNRs with NIR laser therapy can selectively destruct CNE-1 cells while having no effect on normal (rhinal epithelia) cells.

Keywords: photothermal therapy, near-infrared laser, rhinal epithelia cells, cell uptake

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