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Therapeutic Potential of the Ranibizumab Port Delivery System in the Treatment of AMD: Evidence to Date
Authors Chen ER, Kaiser PK
Received 10 March 2020
Accepted for publication 4 May 2020
Published 19 May 2020 Volume 2020:14 Pages 1349—1355
DOI https://doi.org/10.2147/OPTH.S194234
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Eric R Chen,1 Peter K Kaiser2
1School of Medicine, Case Western Reserve University, Cleveland, OH, USA; 2Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
Correspondence: Peter K Kaiser
Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk i3-125, Cleveland, OH 44195, USA
Tel +1 (216) 444-6702
Email kaiserp@ccf.org
Abstract: Age-related macular degeneration (AMD) is one of the leading causes of blindness in older adults worldwide. The advent of intravitreal neutralization of vascular endothelial growth factor (VEGF) has revolutionized the management of patients with neovascular AMD, but current anti-VEGF therapies carry a high threshold of patient burden. The ranibizumab port delivery system (PDS) is an implanted, refillable reservoir that continuously supplies the anti-VEGF medication ranibizumab directly into the vitreous, eliminating the need for frequent intravitreal injections. It has most recently been evaluated in the Phase II LADDER trial demonstrating the efficacy and safety of the PDS, with Phase III trials currently underway. This review presents both the promise and drawbacks of the PDS in the treatment of AMD from the current literature.
Keywords: neovascular age-related macular degeneration, ranibizumab, port delivery system, vascular endothelial growth factor
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