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The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions

Authors Wohlrab J, Voß F, Müller C, Brenn LC

Received 31 May 2013

Accepted for publication 2 August 2013

Published 5 November 2013 Volume 2013:6 Pages 263—271

DOI https://doi.org/10.2147/CCID.S49273

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Johannes Wohlrab,1 Franziska Voß,2 Christian Müller,2 Lars C Brenn2

1Department of Dermatology and Venereology, Martin Luther University of Halle-Wittenberg, Halle, 2Department of Medical Science and Operations, Riemser Pharma GmbH, Greifswald, Germany

Background: Frequent outbreak of herpes labialis can affect quality of life by prodromes like burning, itching, and swelling. Topical applied preparations aim to shorten the duration of symptoms, inhibit the virus replication and/or accelerate the healing process. Local concentrated heat (LCH) can reduce burning, itching, or swelling of the skin by influence of mechano-heat sensitive afferent neurons.
Patients and methods: To examine the effectiveness of two different topical applications (LCH versus topical acyclovir [TACV]) under real life conditions, we conducted a prospective, observational, reference-controlled cohort pilot study with 103 patients. Occurrence of prodromal burning, itching, swelling, and quality of life were assessed.
Results: The LCH observation group (OG) showed a significantly faster improvement in all symptoms after 1-day of application than the TACV OG. The burden and duration of disease was lower and shorter in the LCH OG than in the TACV OG.
Conclusions: The prodromal symptoms in recurrent herpes labialis were attenuated more effectively by LCH than by TACV.

Keywords: herpes labialis, local concentrated heat, acyclovir

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