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The use of amniotic membrane in trabeculectomy for the treatment of primary open-angle glaucoma: a prospective study

Authors Stavrakas P, Georgopoulos G, Milia M, Papaconstantinou D, Bafa, Stavrakas, Moschos

Received 10 October 2011

Accepted for publication 21 November 2011

Published 2 February 2012 Volume 2012:6 Pages 205—212


Review by Single anonymous peer review

Peer reviewer comments 2

Panagiotis Stavrakas1, Gerasimos Georgopoulos1, Maria Milia1, Dimitris Papaconstantinou1, Maria Bafa2, Efthymios Stavrakas2, Mihalis Moschos1
Department of Ophthalmology, University of Athens Medical School, General Hospital of Athens (Geniko Kratiko Hospital), Athens, Greece; 2Department of Ophthalmology, Thriassio General Hospital, Athens, Greece

Background: To investigate the effectiveness of amniotic membrane transplantation (AMT) on improving the outcomes of trabeculectomy in primary open-angle glaucoma (POAG).
Methods: Fifty-nine eyes affected by primary open-angle glaucoma were enrolled in this prospective randomized study. Thirty-two eyes underwent amnion-shielded trabeculectomy (study group) and 27 eyes underwent trabeculectomy without any antimetabolites (control group). Success was defined as intraocular pressure (IOP) <21 mmHg without any medications at 24 months follow-up. The two groups were compared in terms of IOP, bleb morphology, bleb survival and risk of failure, glaucoma medications, and complications.
Results: There was no statistically significant difference in terms of postoperative IOP between the two groups and at 24 months median IOP was 15.5 mmHg for the AMT group and 16 mmHg for the control group. IOP postoperative reduction was 8 mmHg for the AMT group versus 6 mmHg for the non AMT group (P = 0.276). Two patients from the study group developed IOP >21 mmHg in contrast to seven patients from the classic trabeculectomy group. The study group had 61.0% less risk of developing IOP >21 mmHg (P = 0.203). No major complications in the AMT group were observed. AMT blebs were diffuse with mild vascularization.
Conclusion: In patients with POAG, AMT showed favorable effects on bleb survival, however data failed to provide firm evidence that AMT could be used as a routine procedure in trabeculectomy.

Keywords: amniotic membrane, trabeculectomy, primary open-angle glaucoma, glaucoma filtering bleb

In memory of Professor Mihalis Moschos. "We thank him for his encouragement as well as his leadership and commitment to public health."

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