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The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat

Authors Tan HB, Kang X, Lu SH, Liu L

Received 2 October 2014

Accepted for publication 9 November 2014

Published 16 February 2015 Volume 2015:10 Pages 487—490

DOI https://doi.org/10.2147/CIA.S75319

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Zhi-Ying Wu

HaiBo Tan,1,* Xin Kang,2,* ShiHeng Lu,1 Lin Liu1

1Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People’s Republic of China; 2Department of Clinical Pharmacology, Changhai Hospital Affiliated Second Military Medical University, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Abstract: Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results showed that BMSCs significantly promoted the regeneration of injured axons compared with phosphate buffered saline alone. Therefore, BMSC transplantation may be effective for the treatment of central nervous system disorders.

Keywords: bone marrow mesenchymal stem cell, axonal regeneration, rat optic nerve crush, nervous system disorders

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