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The role of transdermal estrogen sprays and estradiol topical emulsion in the management of menopause-associated vasomotor symptoms

Authors Egras A, Umland E

Published 10 May 2010 Volume 2010:3 Pages 147—151

DOI https://doi.org/10.2147/IJGM.S4336

Review by Single-blind

Peer reviewer comments 3


Amy M Egras, Elena M Umland

Jefferson School of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USA

Abstract: Vasomotor symptoms (VMS) are among the most bothersome complaints of postmenopausal women. To date, the most widely studied and effective treatment for VMS is hormone replacement therapy, consisting of estrogen (in women without a uterus) or estrogen plus progestin (in women with a uterus). Traditionally, oral estrogens have been used for treatment. However, over the years, additional estrogen formulations have been developed including transdermal patches; vaginal rings, creams, and tablets; and injectable preparations. Two newer formulations are transdermal estrogen spray and estradiol topical emulsion. This review evaluates the current literature assessing the use of these two newer formulations for the treatment of VMS associated with menopause.

Keywords: menopause, vasomotor symptoms, transdermal estrogen spray, estradiol topical emulsion

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