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The role of endoscopic therapy in obesity management: intragastric balloons and aspiration therapy

Authors Kumar N, Sullivan S, Thompson CC

Received 4 October 2016

Accepted for publication 26 January 2017

Published 6 July 2017 Volume 2017:10 Pages 311—316

DOI https://doi.org/10.2147/DMSO.S95118

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Nitin Kumar,1 Shelby Sullivan,2 Christopher C Thompson3

1Bariatric Endoscopy Institute, Addison, IL, 2Gastroenterology Bariatric and Metabolic Program, University of Colorado School of Medicine, Denver, CO, 3Gastroenterology and Therapeutic Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Abstract: Weight management is increasingly incorporating endoscopic bariatric therapy (EBT). As the global burden of obesity and its comorbidities has increased, it is evident that novel therapeutic approaches will be necessary to address the obesity epidemic. EBTs offer greater efficacy than diet and lifestyle modification and lower invasiveness than bariatric surgery. The US Food and Drug Administration has approved two intragastric balloons and aspiration therapy for the treatment of obesity: Apollo Orbera is indicated for the treatment of Class I and Class II obesity, Re Shape Integrated Dual Balloon system is indicated for the same range with a comorbidity, and Aspire Bariatrics AspireAssist is approved for patients with a body mass index of 35–55 kg/m2. These devices have proven safe and effective in clinical trials and are gaining commercial acceptance in the USA; the Orbera has been used extensively outside the USA for over 20 years. These devices will need to be delivered in the context of a multidisciplinary weight loss program, integrating comprehensive care of obesity. Patient selection is important, and ensuring appropriate patient expectations and understanding of alternatives such as pharmacologic therapy and surgery is essential. With several EBTs on the horizon, patients with obesity will have an even broader array of safe and effective options for weight management in the future.

Keywords: intragastric balloon, Orbera, ReShape, AspireAssist, aspiration therapy, weight loss

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