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The role of EGFR-targeting strategies in the treatment of head and neck cancer

Authors Dequanter D, Shahla M, paulus P, Lothaire P

Received 16 March 2012

Accepted for publication 20 June 2012

Published 27 July 2012 Volume 2012:5 Pages 127—131

DOI https://doi.org/10.2147/OTT.S31863

Review by Single anonymous peer review

Peer reviewer comments 4

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Didier Dequanter, Mohammad Shahla, Pascal Paulus, Philippe H Lothaire

Department of Surgery, CHU Charleroi (Hopital Andre Vésale), Montigny le Tilleul, Belgium

Abstract: With its targeted mechanism of action and synergistic activity with current treatment modalities, cetuximab is a potentially valuable treatment option for patients with recurrent and/or metastatic squamous cell cancer of the head and neck who have progressed on cisplatin-based chemotherapy. The use of cetuximab in combination with radiotherapy as definitive treatment for locoregionally advanced squamous cell cancer of the head and neck is generally restricted to patients unfit to receive cisplatin-based chemoradiation, which is still considered the standard of care. The effect of this epidermal growth factor receptor antagonist occurs without any change in the pattern and the severity of toxicity usually associated with head and neck radiation.

Keywords: cetuximab, SCCHN, radiotherapy

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