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The relationship between plasma lipids, oxidant–antioxidant status, and glycated proteins in individuals at risk for atherosclerosis

Authors Dzięgielewska-Gęsiak S, Płóciniczak A, Wilemska-Kucharzewska K, Kokot T, Muc-Wierzgoń M, Wysocka E

Received 26 November 2018

Accepted for publication 1 March 2019

Published 9 May 2019 Volume 2019:14 Pages 789—796

DOI https://doi.org/10.2147/CIA.S196016

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Sylwia Dzięgielewska-Gęsiak,1 Alicja Płóciniczak,2 Katarzyna Wilemska-Kucharzewska,1 Teresa Kokot,1 Małgorzata Muc-Wierzgoń,1 Ewa Wysocka2

1Department of Internal Medicine, Medical University of Silesia, 44-902 Bytom, Poland; 2Department of Laboratory Diagnostics, Poznan University of Medical Science, 60-569 Poznan, Poland

Objective: Ageing is one of the major risks for atherosclerosis. The age-related changes of interactions between plasma lipids, oxidative stress, antioxidant defense, and glycation processes are still not established while we age. Thus, the aim of the study was to analyze such relationships in individuals at risk for atherosclerosis due to their age.
Methods: Elderly and middle-aged persons with no acute disease or severe chronic disorder were assessed. Fasting plasma lipids (total cholesterol (T-C), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, and triacylglycerols), thiobarbituric acid reacting substances (TBARS), plasma total antioxidant status (TAS), and glucose and glycated proteins (fructosamine (FA) and glycated hemoglobin (HbA1c)) were determined. An oral glucose tolerance test allowed exclusion of persons with type 2 diabetes.
Results: Lipid profiles were significantly profitable, increased HDL-C especially (p<0.0001), in the elderly versus middle-aged group. Decreased TBARS and TAS were found in the elderly versus middle-aged group (p=0.0001 and p=0.00002, respectively). Increased fructosamine was found in the elderly (255±30 μmol/L) versus middle-aged (236±33 μmol/L) group (p=0.006). Multiple regression analysis showed that in the middle-aged group TBARS correlated with T-C and HDL-C, and in the elderly group with HbA1c and FA independently of other factors.
Conclusion: The factors which have an impact on oxidant–antioxidant status are crucial to understanding the pathomechanisms of senescence as well as the development of chronic diseases. Healthy aging may be maintained throughout proper lipid control. Moreover, data support the premise that the balance between lipid metabolism and oxidative stress may play a role in the initial phases of glycation plasma proteins particularly among elderly persons.

Keywords: plasma lipids, oxidant-antioxidant markers, glycated proteins, aging, atherosclerosis risk

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