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The Relationship Between Fasting Blood Glucose Levels and First Ischemic Stroke in Elderly Hypertensive Patients

Authors Huang Y, Lo K, Liu X, Tang S, Huang C, Feng Y

Received 17 May 2020

Accepted for publication 1 July 2020

Published 12 July 2020 Volume 2020:13 Pages 777—784

DOI https://doi.org/10.2147/RMHP.S263213

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Marco Carotenuto


Yu-qing Huang,1,* Kenneth Lo,1,* Xiao-cong Liu,1 Song-tao Tang,2 Cheng Huang,1 Ying-qing Feng1

1Department of Cardiology, Guangdong Cardiovascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, People’s Republic of China; 2Department of Internal Medicine, Community Health Center of Liaobu County, Dongguan, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Ying-qing Feng; Cheng Huang
Department of Cardiology, Guangdong Cardiovascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou 510080, People’s Republic of China
Tel/ Fax +86-20-83827812
Email 651792209@qq.com linfeng7822@sina.com

Objective: The relationship between fasting blood glucose and first ischemic stroke in older adults was unclear, so we explored this association among older patients with hypertension in China.
Methods: We recruited hypertensive participants with 60 or more of age. Fasting blood glucose concentrations were categorized into quartiles. Hazard ratio (HR) and 95% confidence interval (CI) for ischemic stroke were estimated using multivariate Cox regression analysis and subgroup analysis.
Results: A total of 3310 (1474 (44.53%) male) patients with mean age of 71.41± 7.20 years were included. During the mean follow-up period of 5.5 years, 206 cases of ischemic stroke occurred. After adjusting for potential confounding variables, multivariate adjusted HRs for each standard deviation increment of fasting blood glucose, the risk of ischemic stroke increased by 11% (95% CI: 1.03, 1.21; P= 0.008). In addition, when using the lowest group (Q1) as reference, the multivariate adjusted HRs for first ischemic stroke were 1.76 (95% CI: 1.08, 2.86; P=0.023), 1.73 (95% CI: 1.06, 2.81; P=0.027) and 2.42 (95% CI: 1.49, 3.93; P< 0.001) (P for trend< 0.001). Subgroup analysis revealed that the association between fasting blood glucose and the risk of ischemic stroke was higher in male (HR: 1.22 vs 1.10), those with uncontrolled hypertension (HR: 1.22 vs 1.10), subjects with diabetes (HR: 1.19 vs 1.10), overweight (HR: 1.19 vs 1.09), smoking habits (HR: 1.33 vs 1.13) and those whose eGFR< 90 (HR: 1.16 vs 1.09).
Conclusion: Fasting blood glucose was an independent risk factor for the first ischemic stroke among older adults with hypertension. Managing fasting blood glucose may be beneficial for participants with diabetes, poorly controlled blood pressure, had smoking habits, being overweight, and with reduced renal function.

Keywords: fasting blood glucose, ischemic stroke, elderly, hypertension, community

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