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The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women

Authors Yao M, Liu H, Li B, Liu Y, Mu Y

Received 13 November 2020

Accepted for publication 5 February 2021

Published 25 February 2021 Volume 2021:14 Pages 847—856

DOI https://doi.org/10.2147/DMSO.S292041

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Ming-Hui Zou


Mingyan Yao,1,2,* Hongzhou Liu,1,* Bing Li,1 Yang Liu,1 Yiming Mu1

1Department of Endocrinology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding, 071000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yiming Mu
Department of Endocrinology, Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Beijing, 100853, People’s Republic of China
Email [email protected]

Purpose: There is a close correlation between menopausal age and cardiovascular disease (CVD) risk. Some research suggests that this risk is attributable to an elevated urinary albumin-creatinine ratio (UACR), but further work is needed to explore the link between UACR and age at time of menopause.
Patients and Methods: Data analyzed in the present study were derived from seven regional centers participating in the REACTION study. A total of 21,672 postmenopausal women met with our study inclusion and exclusion criteria, and were split into three groups based upon their age at onset of natural menopause. A UACR ≥ 30 mg/g was the primary outcome measure for this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a logistic regression approach.
Results: Relative to women who were 46– 50 years old at time of natural menopause, those with an earlier onset of menopause (≤ 45 years) exhibited an increased risk of UACR elevation following adjustment for confounding variables (OR: 1.18, 95% CI: 1.04– 1.33), whereas the opposite was true for women with a later age of menopause onset (> 50 years) (OR: 0.86, 95% CI: 0.78– 0.94). For every 1-year delay in the onset of menopause, UACR risk fell by 3% (OR: 0.97, 95% CI: 0.96– 0.98).
Conclusion: In summary, early menopause (≤ 45 years old) was linked to a higher risk of UACR elevation in postmenopausal women. However, further work will be needed to understand the mechanistic basis for these findings.

Keywords: age, urinary albumin-creatinine ratio, menopause

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