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The recent advances of phenotypes in acute exacerbations of COPD

Authors Zhou A, Zhou Z, Zhao Y, Chen P

Received 24 November 2016

Accepted for publication 19 February 2017

Published 27 March 2017 Volume 2017:12 Pages 1009—1018

DOI https://doi.org/10.2147/COPD.S128604

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Professor Hsiao-Chi Chuang

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell

Aiyuan Zhou,1–3 Zijing Zhou,1–3 Yiyang Zhao,1–3 Ping Chen1–3

1Department of Respiratory Medicine, The Second Xiangya Hospital, 2Research Unit of Respiratory Disease, 3Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, People’s Republic of China

Abstract: Exacerbations of COPD are clinically relevant events with therapeutic and prognostic implications. Yet, significant heterogeneity of clinical presentation and disease progression exists within acute exacerbations of COPD (AECOPD). Currently, different phenotypes have been widely used to describe the characteristics among patients with AECOPD. This has proved to be significant in the treatment and prediction of the outcomes of the disease. In this review of published literature, the phenotypes of AECOPD were classified according to etiology, inflammatory biomarkers, clinical manifestation, comorbidity, the frequency of exacerbations, and so on. This review concentrates on advancements in the use of phenotypes of AECOPD.

Keywords: COPD, acute exacerbation, phenotype, treatment, prognosis

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