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The proliferation of cervical cancer is promoted by miRNA-125b through the regulation of the HMGA1

Authors Sun B, Zhang Y, Zhou L, Yin L, Li F, Li C, Xia J

Received 11 December 2018

Accepted for publication 19 February 2019

Published 11 April 2019 Volume 2019:12 Pages 2767—2776

DOI https://doi.org/10.2147/OTT.S197740

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Aruna Narula

Peer reviewer comments 3

Editor who approved publication: Dr Sanjeev Srivastava


Bingmei Sun, Ying Zhang, Lianxiang Zhou, Linin Yin, Fei Li, Chao Li, Jiayu Xia

Department of Gynaecology and Obstetrics, Linyi Central Hospital, Linyi 276400, Shandong Province, China

Background: It has been reported that miRNA-125b is associated with carcinogenesis and development of several different kinds of cancers. Nevertheless, there is no clarity regarding the significance and mechanism of action of miR-125b in clinical practice for cervical cancer (CC).
Materials and methods: In the current investigation, the expression of miR-125b in cervical clinical specimens and CC cell lines was analyzed via real-time quantitative PCR, and the relationship of miR-125b with the chromatin-associated protein high mobility group A (HMGA1) expression and clinicopathological parameters of CC patients was explored.
Results: The results indicated that miR-125b expression was remarkably upregulated in CC cell lines as well as in the tissues of humans. miR-125b overexpression was significantly related to a decrease in HMGA1 expression, progression-free survival, overall survival, and prognosis as well. Besides, knockdown of miR-125b inhibited proliferation and colony formation in SW756 and C4-1 cells, where the 3'-UTR of HMGA1 mRNA was directly targeted. Moreover, PI3K/Akt pathway was regulated by miR-125b through suppression of HMGA1.
Conclusion: These findings illustrated that a new regulatory role of HMGA1 is involved in the progression of CC. Our data demonstrated that miR-125b could play a critical role in the carcinogenesis and progression of CC, revealing that miR-125b might serve as a potential new target for treating CC.

Keywords: cervical cancer, CC, miR-125b, high mobility group A, HMGA1, progression-free survival, PFS, overall survival, OS, prognosis

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