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The Prognostic Factors of Preoperative Prognostic Nutritional Index and Radiological Findings of Solid Pseudopapillary Tumors of Pancreas: A Single-Center Experience of 14 Years

Authors Song H, Dong M

Received 7 April 2020

Accepted for publication 28 June 2020

Published 12 July 2020 Volume 2020:12 Pages 5689—5699

DOI https://doi.org/10.2147/CMAR.S256650

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Ahmet Emre Eskazan


He Song, Ming Dong

Department of Gastrointestinal Surgery of the First Hospital of China Medical University, Shenyang 110001, People’s Republic of China

Correspondence: Ming Dong Tel +8613804900651
Fax +862483282881
Email dongming@cmu.edu.cn

Introduction: Solid pseudopapillary tumors of pancreas (SPTP) is an indolent rare tumor with malignant potential. The prediction of malignancy is an enigma. The aim of this study is to explore the relationship between operative measurements and malignancy prognosis of SPTP patients.
Methods: A cohort of consecutive 102 patients were enrolled in this study. Preoperative measurements and clinical outcomes were analyzed.
Results: Eighteen patients (17.6%) were confirmed as malignant. The malignant SPTP of the optimal cut-off value was 47.9 (p=0.012) for prognostic nutritional index (PNI). The value of PNI≤ 47.9 and incomplete capsule were significantly correlated with malignancy. Univariate analysis showed that the PNI≤ 47.9 (p=0.013) and incomplete capsule (p< 0.001) were predictors of disease-specific survival (DSS). Multivariate analysis identified the PNI≤ 47.9 (p=0.036) and incomplete capsule (p=0.023) as the independent prognostic factors of DSS. The new score of 0,1,2 based on PNI and capsule presence stratified the patients into 3 groups. The patients with low PNI and incomplete capsule achieved the worst prognosis.
Conclusion: The combination test of operative PNI and capsule presence would be a reliable indicator of the aggressive natural history of SPTP.

Keywords: solid pseudopapillary tumor, pancreas, prognostic nutritional index, disease-specific survival

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