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The predictive value of arterial stiffness on major adverse cardiovascular events in individuals with mildly impaired renal function

Authors Han J, Wang X, Ye P, Cao R, Yang X, Xiao W, Zhang Y, Bai Y, Wu H

Received 22 March 2016

Accepted for publication 11 May 2016

Published 29 August 2016 Volume 2016:11 Pages 1175—1181

DOI https://doi.org/10.2147/CIA.S109009

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Zhi-Ying Wu

Jie Han,* Xiaona Wang,* Ping Ye, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Yongyi Bai, Hongmei Wu

Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China

*These authors contributed equally to this work

Objectives: Despite growing evidence that arterial stiffness has important predictive value for cardiovascular disease in patients with advanced stages of chronic kidney disease, the predictive significance of arterial stiffness in individuals with mildly impaired renal function has not been established. The aim of this study was to evaluate the predictive value of arterial stiffness on cardiovascular disease in this specific population.
Materials and methods: We analyzed measurements of arterial stiffness (carotid–femoral pulse-wave velocity [cf-PWV]) and the incidence of major adverse cardiovascular events (MACEs) in 1,499 subjects from a 4.8-year longitudinal study.
Results:
A multivariate Cox proportional-hazard regression analysis showed that in individuals with normal renal function (estimated glomerular filtration rate [eGFR] ≥90 mL/min/1.73 m2), the baseline cf-PWV was not associated with occurrence of MACEs (hazard ratio 1.398, 95% confidence interval 0.748–2.613; P=0.293). In individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m2), a higher baseline cf-PWV level was associated with a higher risk of MACEs (hazard ratio 2.334, 95% confidence interval 1.082–5.036; P=0.031).
Conclusion:
Arterial stiffness is a moderate and independent predictive factor for MACEs in individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m2).

Keywords: epidemiology, arterial stiffness, impaired renal function, predictive value, MACEs

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