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The Persistence of Opioid Use Following Surgical Admission: An Australian Single-Site Retrospective Cohort Study

Authors Veal F, Thompson A, Halliday S, Boyles P, Orlikowski C, Bereznicki L

Received 23 October 2019

Accepted for publication 7 March 2020

Published 5 April 2020 Volume 2020:13 Pages 703—708

DOI https://doi.org/10.2147/JPR.S235764

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr E Alfonso Romero-Sandoval


Felicity Veal,1 Angus Thompson,1 Samuel Halliday,2 Peter Boyles,2 Chris Orlikowski,3 Luke Bereznicki1

1Unit for Medication Outcomes Research & Education (UMORE), School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Tasmania, Australia; 2Department of Health, Hobart, Tasmania, Australia; 3Federal Pain Clinic, Hobart, Tasmania, Australia

Correspondence: Felicity Veal
Unit for Medication Outcomes Research & Education (UMORE), School of Pharmacy and Pharmacology, University of Tasmania, Private Bag 26, Hobart, Tasmania 7001, Australia
Tel +61 36 226 2312
Fax +61 36 226 7627
Email Felicity.Veal@utas.edu.au

Background: Acute pain is common following surgery, with opioids frequently employed in its management. Studies indicate that commencing an opioid during a hospital admission increases the likelihood of long-term use. This study aimed to identify the prevalence of opioid persistence amongst opioid-naïve patients following surgery as well as the indication for use.
Methods: A retrospective review of patients who underwent a surgical procedure at the Royal Hobart Hospital, Tasmania, Australia, between August and September 2016 was undertaken. Patients were linked to the Tasmanian real-time prescription monitoring database to ascertain if they were subsequently dispensed a Schedule 8 opioid (morphine, codeine oxycodone, buprenorphine, hydromorphone, fentanyl, methadone, or tapentadol) and the indication for use.
Results: Of the 3275 hospital admissions, 1015 opioid-naïve patients were eligible for inclusion. Schedule 8 opioids were dispensed at or within 2 days of discharge in 41.7% of admissions. Thirty-nine (3.9%) patients received prescribed opioids 2-months post-discharge; 1.8% of the patients were approved by State Health to be prescribed Schedule 8 opioids regularly for a chronic condition at 6 months, and 1.3% received infrequent or one-off prescriptions for Schedule 8 opioids at 6 months. Thirteen (1.3%) patients continued Schedule 8 opioids for at least 6 months following their surgery, with the indication for treatment either related to the surgery or the condition which surgery was sought for.
Conclusion: This study found that there was a low rate of Schedule 8 opioid persistence following surgery, indicating post-surgical pain is not a significant driver for persistent opioid use.

Keywords: opioids, post-operative, persistence, prescribing

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