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The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Authors Sha X, Dai Y, Song X, Liu S, Zhang S, Li J

Received 5 November 2020

Accepted for publication 21 December 2020

Published 28 January 2021 Volume 2021:16 Pages 701—714

DOI https://doi.org/10.2147/IJN.S290537

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Yan Shen


Xuan Sha,1,2 Yue Dai,1,2 Xiaoxi Song,1,2 Siwen Liu,1,2 Shuai Zhang,1,2 Jingjing Li1,2

1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 2School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China

Correspondence: Jingjing Li
Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China
Tel +8651683262623
Email qingchao0124@163.com

Abstract: Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.

Keywords: mesoporous silica, nanomaterials, diagnosis, drug delivery, atherosclerosis

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