Back to Journals » Psychology Research and Behavior Management » Volume 11

The neuropsychology of emerging psychosis and the role of working memory in episodic memory encoding

Authors Pflueger MO, Calabrese P, Studerus E, Zimmermann R, Gschwandtner U, Borgwardt S, Aston J, Stieglitz RD, Riecher-Rössler A

Received 18 August 2017

Accepted for publication 24 November 2017

Published 10 May 2018 Volume 2018:11 Pages 157—168

DOI https://doi.org/10.2147/PRBM.S149425

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Igor Elman

Marlon O Pflueger,1 Pasquale Calabrese,2 Erich Studerus,3 Ronan Zimmermann,4 Ute Gschwandtner,4 Stefan Borgwardt,5 Jacqueline Aston,3 Rolf-Dieter Stieglitz,6 Anita Riecher-Rössler3

1Department of Forensic Psychiatry, University of Basel Psychiatric Clinics, Basel, Switzerland; 2Division of Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland; 3Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; 4Department of Neurology and Neurosurgery, Hospital of the University of Basel, Basel, Switzerland; 5Department of Psychiatry (UPK), University of Basel, Basel, Switzerland; 6Division of Clinical Psychology and Psychiatry, University of Basel, Basel, Switzerland

Background: Episodic memory encoding and working memory (WM) deficits are among the first cognitive signs and symptoms in the course of schizophrenia spectrum disorders. However, it is not clear whether the deficit pattern is generalized or specific in nature. We hypothesized that encoding deficits at an early stage of the disease might be due to the more fundamental WM deficits.
Methods: We examined episodic memory encoding and WM by administering the California Verbal Learning Test, a 2-back task, and the Wisconsin Card Sorting Test in 90 first-episode psychosis (FE) patients and 116 individuals with an at-risk mental state for psychosis (ARMS) compared to 57 healthy subjects.
Results: Learning progress, but not span of apprehension, was diminished to a similar extent in both the ARMS and the FE. We showed that this was due to WM impairment by applying a structural equation approach.
Conclusion: Thus, we conclude that verbal memory encoding deficits are secondary to primary WM impairment in emerging psychosis.

Keywords: at-risk mental state, first-episode psychosis, cognition, serial position effect, recency, semantic cluster ratio, 2-back task, rate of learning

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]