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The molecular profile of luminal B breast cancer

Authors Creighton C

Received 15 June 2012

Accepted for publication 26 July 2012

Published 24 August 2012 Volume 2012:6 Pages 289—297

DOI https://doi.org/10.2147/BTT.S29923

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Chad J Creighton

Department of Medicine and Dan L Duncan Cancer Center Division of Biostatistics. Baylor College of Medicine, Houston, TX, USA

Abstract: Molecular profiling studies have found that estrogen receptor-positive (ER+) human breast cancers are comprised of at least two distinct diseases with differing biologies. With the advent of DNA microarrays, global gene expression patterns were used to define the luminal A and luminal B subtypes of ER+ breast cancer, with luminal B cancers showing a more aggressive phenotype including substantially worse outcomes in patients. The luminal B subtype designation could be considered a surrogate for those ER+ tumors having low progesterone receptors, high proliferation, high grade, and predicted poor response to hormone therapy. While they express estrogen receptors, luminal B cancers do not show a corresponding expression of estrogen-regulated genes, and may therefore rely upon alternative pathways for growth. At the molecular level, luminal B cancers appear dramatically distinct from luminal A cancers, at the levels of gene expression, gene copy, somatic mutation, and DNA methylation; luminal B cancers are also genetically and genomically altered to a greater extent than luminal A cancers. While, in the clinical setting, luminal B is typically regarded as an ER+, hormone-sensitive disease, more research is needed into how to better treat it. Comprehensive profiling initiatives, such as The Cancer Genome Atlas, have recently provided us a catalog of mutated or copy altered genes, from which new therapeutic targets could potentially be mined. Candidate pathways that might be targeted in luminal B include those involving growth factor receptors, including HER2 and EGFR, as well as PI3K/Akt/mTor.

Keywords: luminal B, molecular profiling, integrative analysis, breast cancer, TCGA

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