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The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake

Authors Sari DK, Sari LM, Laksmi LI, Farhat

Received 20 January 2021

Accepted for publication 26 February 2021

Published 11 March 2021 Volume 2021:14 Pages 841—850

DOI https://doi.org/10.2147/IJGM.S302912

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser


Video abstract presented by Dina Keumala Sari.

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Dina Keumala Sari,1 Liza Meutia Sari,2 Lidya Imelda Laksmi,3 Farhat4

1Nutrition Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; 2Oral Medicine Department, Faculty of Dentistry, Universitas Syah Kuala, Banda Aceh, Indonesia; 3Anatomy Pathology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; 4Ear, Nose, Throat, Head and Neck Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Correspondence: Dina Keumala Sari
Nutrition Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Ring Road, Komp. Tasbih 2, Blok 5, No. 126, Medan, North Sumatra, 20128, Indonesia
Tel +62 81397177693
Email [email protected]

Purpose: The routine examination of vitamin D levels is carried out by checking serum 25(OH)D levels, while serum 1.25(OH)D levels are less frequently utilized. The proposition that testing for salivary vitamin D can show a correlation with serum levels in healthy people is questionable, especially with low vitamin D intake. This study aimed to find the correlation between vitamin D levels, which were assessed as 25(OH)D and 1.25(OH)D in saliva, and serum 25(OH)D and 1.25(OH)D levels in people with low vitamin D intake.
Patients and Methods: This study is a cross-sectional study involving healthy men and women, aged 18– 60 years, carried out from August to November, 2020, in North Sumatra Province, Indonesia. The parameters studied were the 25(OH)D and 1.25(OH)D levels in saliva and serum, and vitamin D intake. The statistical analysis used was the Spearman correlation test, performed to determine the correlation between each parameter.
Results: This study involved 56 study subjects, who were rural adults (male or female) with a 78.6% deficiency in 25(OH)D found by examining saliva, and a 76.8% deficiency found by examining the serum. All of the subjects were categorized as having low vitamin D intake (less than 15 micrograms per day). The analysis showed a moderate correlation between levels of saliva 25(OH)D and serum 25(OH)D (p = 0.424), and a weak correlation between levels of saliva 1.25(OH)D and serum 25(OH)D (p = 0.339).
Conclusion: In people with low vitamin D intake, there was a moderate correlation between serum 25(OH)D and saliva, but a weak correlation was found in the 1.25(OH)D assay. The use of saliva 25(OH)D levels to detect 25(OH)D in the circulation is a possible non-invasive alternative to serum testing.

Keywords: cross-sectional study, deficiency, food sources, non-invasive, rural, vitamin D

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