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The miR-200 family: multiple effects on gliomas

Authors Peng L, Fu J, Ming Y

Received 27 December 2017

Accepted for publication 14 May 2018

Published 13 July 2018 Volume 2018:10 Pages 1987—1992

DOI https://doi.org/10.2147/CMAR.S160945

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Kenan Onel


Lilei Peng,1 Jie Fu,2 Yang Ming1

1Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China; 2Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China

Abstract: Gliomas are the most common type of primary brain tumors. MicroRNAs (miRNAs) are small noncoding RNAs that can epigenetically regulate target gene expression. The microRNA 200 family includes miR-200a, 200b, 200c, 141 and 429. Numerous studies have indicated that members of the miR-200 family play an important role in glioma development and metastasis. In this review, we summarize the data from various studies and highlight the effects of miR-200 on glioma metastasis, therapeutic response and prognosis.

Keywords: glioma, miR-200 family, metastasis, chemoresistance, radioresistance

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