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The MIF -173G/C polymorphism and risk of coal workers' pneumoconiosis in a Chinese population

Authors Jin, Ji, Wang, Song, Jia X, Hou, Wang, Wang, Ni C

Received 29 January 2012

Accepted for publication 26 March 2012

Published 14 May 2012 Volume 2012:4 Pages 37—42

DOI https://doi.org/10.2147/IJICMR.S30329

Review by Single-blind

Peer reviewer comments 3


Kexin Jin,1,* Xiaoming Ji,1,* Shasha Wang,1 Zhifang Song,2 Xiaomin Jia,2 Zhiguo Hou,1 Ting Wang,1 Meilin Wang,1 Chunhui Ni1

1Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing, 2General Hospital of Xuzhou Mining Business Group Co, Ltd, Xuzhou, People's Republic of China

*These authors contributed equally to this work

Objective: To investigate the possible relationship between macrophage migration inhibitory factor (MIF) -173 polymorphism (rs755622) and susceptibility to coal workers' pneumoconiosis (CWP) in a Chinese population.
Methods: A total of 699 patients with CWP and 677 controls were genotyped for the polymorphism by TaqMan method.
Results: Our results showed that the MIF -173CC genotype was associated with a significantly decreased risk of CWP (adjusted odds ratio = 0.44, 95% confidence interval = 0.22–0.85), compared with the GG/GC genotype, particularly among smokers.
Conclusion: Our results indicate that the functional MIF -173G/C polymorphism is involved in the etiology of CWP and susceptibility to this disease. Further studies are warranted to validate our findings.

Keywords: MIF, polymorphism, coal workers' pneumoconiosis, molecular epidemiology

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