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The Magnitude, Types, and Roles of Social Support in Diabetes Management among Diabetics’ in Southern Ethiopia: a Multilevel, Multicenter Cross-Sectional Study

Authors Jaafaripooyan E, Habebo TT , Mosadeghrad AM, Foroushani AR , Anshebo DG 

Received 10 August 2021

Accepted for publication 27 September 2021

Published 19 October 2021 Volume 2021:14 Pages 4307—4319


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Juei-Tang Cheng

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Ebrahim Jaafaripooyan,1 Teshome Tesfaye Habebo,1,2 Ali Mohammad Mosadeghrad,1 Abbas Rahimi Foroushani,3 Dawit G/Michael Anshebo4

1Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran (the Islamic Republic); 2Disease Prevention and Control Directorate, Kembata Tembaro Zone Health Department, Durame, SNNPRS, Ethiopia; 3Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran (the Islamic Republic); 4Public Health Emergency Management Directorate (PHEM), Kembata Tembaro Zone Health Department, Durame, SNNPRS, Ethiopia

Correspondence: Teshome Tesfaye Habebo Email [email protected]

Introduction: Lifelong medical management is the main intervention to reduce diabetes-related morbidities and premature deaths; yet, social support can be a vital intervention to improve diabetics’ health. Therefore, this study aimed to determine the magnitude, types, and role of social support in diabetes management in southern Ethiopia.
Methods: A multi-stage systematic sampling was applied to recruit 634 adult diabetics from the three-tiered healthcare system in the region. We proportionally distributed the sample size between randomly selected ten health-care facilities across the hierarchy. Pretested questionnaires and checklist; Epi-Info, and SPSS software used for data collection; entry, and analyses, respectively, and the statistical significance was determined at a P-value ≤ 0.05.
Results: A total of 240 females and 356 males completed the study, and the overall magnitude of the social support was 50.20% [95% CI: 46.19%, 54.21%], and it was categorized into non-material and material with 44.13% [95% CI: 40.14%, 48.12%] and 34.23% [95% CI: 30.42%, 38.04%] magnitudes, respectively, and social support was left to the patients’ families and friends whereas formal institutions and the public sectors were rarely offering when the patients needed it. Though sex, educational level, and health-care hierarchy were not significantly associated with the social support, residence, some occupations, presence of diabetic family members, acute medical conditions, blood glucose level, compliance to medical follow-ups, treatment adherence, and taking anti-diabetic drugs a day before the current visit to health-care facility were all statistically significantly associated with social support.
Conclusion: One of every two adult diabetic patients in southern Ethiopia was receiving any social support, and social support for diabetic people reduces medical follow-ups absenteeism, improves treatment adherence, glycemic level controlling, and helps lifestyle modifications. Therefore, to keep diabetic people healthy and achieve diabetes management goals, the Ethiopian healthcare system, institutions, and concerned stakeholders should strengthen the social support for diabetic patients.

Keywords: diabetes mellitus, disease management, magnitude, social support, southern Ethiopia


Diabetes mellitus has become the major health threat for the global community, and this concern is mainly attributable to the increasing disease burden, devastating diabetic complications, loss of productivity, and high health-care costs.1 For example, global estimates indicated there were 151 million diabetics in 2000, and this figure increased by three folds, 463 million, between 2000 and 2019, and the developing countries contributed two-third of the global diabetes burden. Moreover, the projections show unless robust preventive measures are implemented to avert this trend, by 2030, the diabetes burden will rise to 578 million globally.2

Ethiopia is one of the sub-Saharan African countries (SSA) where the diabetes burden is alarmingly increasing. For instance, in 2019, the number of diabetics in Ethiopia was 1.7 million that put the country among the top four leading African countries. However, the international diabetes federation’s (IDF) projection indicates 68.10% of diabetic people in Ethiopia live undiagnosed, and every single hour nearly three peoples’ deaths are attributable to diabetes mellitus.3

Ethiopia’s low socio-economic status, growing demand for healthcare, high communicable diseases burden, increasing non-communicable diseases trends, and poor health-care services quality put the country among the nations with very poor health-related indicators.4–6 Lack of health-care services accessibility and affordability has also become significant challenges for millions of Ethiopians, specifically for the rural and urban poor communities.4,7

Thus, diabetes mellitus became one of the health threats of all population segments, particularly for the poor in developing nations like Ethiopia, and it brings unbearable burdens to the health, social and economic affairs of the people.7 Nevertheless, evidence indicates prevention of the disease progression, specifically the type II DM, is modestly achievable; and accessible and affordable health care for any DM type significantly decreases the negative effects too.8,9 For example, proper management of diabetes mellitus reduces admission rates, health-care costs, and premature death rates, and increases productivity, and improves the quality of life.2

However, in order to achieve the desirable diabetes management goals, cost-effective and ongoing clinical care, preventive practices, and person-centered goal setting and its implementation are more effective than managing the disease and its complications. To this effect, involving the diabetic patients’ families, communities, significant others, and public sectors are vital for the patient to lead healthy and productive life (hereafter social support).7

Social support is an interpersonal bonding system that takes individuals at the center of the support and consists of several triangulating constituents and practices by both individuals themselves and other supporting bodies around them,10 and presented in (Figure 1). Besides, it involves self-evaluation of actual or perceived social ties with families, friends, relatives, colleagues, organizations, and/or significant others that can offer emotional, material, monetary, or personal backing when required.11,12

Figure 1 A conceptual framework on social support for diabetic patients in southern Ethiopia, 2020.

Studies demonstrated that social support for diabetic patients is one of the enabling factors to accept and maintaining good self-care practices in diabetes management.13,14 People who perceive or ensure to have better social networks and support are more likely to demonstrate better health outcomes15 which is also specifically essential in predicting the implementation of healthy practices to manage chronic illnesses like diabetes mellitus.12

For instance, studies confirmed that social support for diabetics’ was positively associated with blood glucose monitoring, good adherence to healthy diets, and doing regular physical exercises. Hence, social support for diabetic patients plays a vital role in enhancing diabetes self-management behaviors and improving clinical outcomes.12 Moreover, better social support yields good health-related decision-making, implementation of healthy behaviors in chronic illness management, and good health status14,16 and it is one of the determinant factors to reduce diabetes-related negative health consequences.17

To this effect, ongoing and focused social supports for diabetics’ from self-help associations, governmental, non-governmental, and faith-based organizations, families, and significant others can be very important and rewarding intervention, Nevertheless, social supports for diabetic patients is not well documented and there is a paucity of evidence on social support in Ethiopia and southern Ethiopia in particular. Therefore, this survey aimed to determine the magnitude, types, and role of social support in diabetes management among diabetic patients, in southern Ethiopia.

The finding of this study will play a vital role to establish evidence-based decision making to improve the health of the diabetic patients in the region in particular and beyond, and the study may be eye-opening research to see diabetes management as comprehensive, continues and participatory rather than merely focusing on clinical practices.

Objectives of the Study

General Objective

  • To determine the social support magnitude, types, and its roles in diabetes management among diabetic patients in southern Ethiopia.

Specific Objectives

  • To determine the magnitude of social support to diabetic patients in southern Ethiopia.
  • To identify the major types of social support that diabetic patients receive in southern Ethiopia.


Study Setting

This study was conducted in south nations’ nationalities and people’s regional state (SNNPRS) of Ethiopia. Hawassa is the capital of SNNPRS, and the city is located at 280 km distance to the south of Addis Ababa (the capital city of Ethiopia). Two of the sixteen zones (sub-provinces: Hadiya and Kembata Tembaro zones) were randomly selected, and the sub-province has dry, temperate, and cold climatic conditions. The main livelihood activities in the study area were un-mechanized agriculture, livestock rearing, and small businesses.

According to the region’s finance and economic development bureau report,18 the 2020/21 projected population was 2,690,735; 15.2% of the population were urban inhabitants, and 50.9% were females.18 Similar to the national administrative structures, each sub-province is administratively divided into districts (woredas), and there were 28 districts (7 urban and 21 rural) in the study area.

The region’s public healthcare system, similar to the national one, is hierarchically organized into a three-tier system: tertiary (referral hospitals), secondary (general hospitals) and primary health-care units, PHCUs (which comprises primary hospitals, health centers, and health posts) in the descending order; except the health posts, all health-care levels deliver diabetes screening and clinical care; however, the service entry point and referral system begin at health centers, where only routine diabetes screening and blood glucose monitoring takes place, through referral hospitals, where specialty services are delivered, and the next upper level serves as an immediate referral center for its lower levels. In sum, there was one referral hospital, one general hospital, six primary hospitals, and 88 health centers, and 102 other health-care facilities such as drug stores and pharmacies in the sub-province.19

Study Design and Period

A facilities-based cross-sectional study was carried out from May 01 to August 30, 2020.

Study Population

Adult diabetic patients who were on routine follow-ups in the health facilities during the study period

Inclusion Criteria

Diabetic patients who were on routine follow-ups at least for one year; age eighteen years and older, Ethiopian citizens, and patients who were willing to participate in the study.

Exclusion Criteria

Patients with communication barriers, psychiatric problems, and unable to communicate due to their underlying medical conditions were excluded.

Sample Size Determination

The sample size (n) required for this study was computed by using the formula to estimate a single population proportion, and the following assumptions were considered to calculate. A 50% proportion (P), 95% confidence level (Zα/2), 5% margin of sampling error (d), 1.5 design effect (D), and 10% attrition rate (equation 1.1).


n = 576 plus 58 (the 10% attrition rate)

Hence, the sample size required to accomplish the study became 634 patients.

The Data Collection Tools

We used semi-structured questionnaires (for patient exit interviews) and checklists (for medical record reviewing). The tool was developed by reviewing the available literature and then contextualized by considering socio-economic, cultural and other related factors in the study area.1,4,7,10,20–23 The tools were prepared in English and translated into the Amharic language, the official language in the study area, and then back into the English language by two different expert translators and then pre-tested and improved accordingly.

Sampling Procedure and Study Population Recruitment

A multi-stage systematic sampling technique was employed to reach the study subjects. Initially, the study region was divided into 16 zones (sub-provinces). Two sub-provinces: Hadiya and Kembata Tembaro zones were selected by lottery method. The two zones were further divided into 28 districts. Eight of 28 districts were randomly chosen, and then all public health facilities in the selected districts were listed in a paper along with their hierarchies.

Then, the only referral hospital (Nigist Ileni Mohamed memorial referral hospital from Hadiya zone), and a general hospital (Dr. Bogalech Gebre memorial general hospital from Kembata Tembaro zone) were purposively chosen. Additionally, four out of the six available primary hospitals along with one of its five satellite health centers were selected randomly from the list. However, health posts were excluded from the list because the health posts do not give any DM-related services to the patients. Based on their last six months’ patient load, the sample size was proportionally distributed among the selected health facilities, and patients who came to the health facilities for routine follow-ups during the data collection period and satisfied the inclusion criteria were systematically selected and invited to participate voluntarily in the study.

Data Collection Procedure

After getting informed written consent from each patient, patients were allowed to choose one of the three commonly spoken languages as media of communication (Amharic, Hadiyissa, or Kambatissa) depending on his/her preference and ability to speak the languages, and then exit interviewing was done. At first socio-demographic related data were collected; to assess the magnitude of the social support single “yes/no” question was asked; and once the patient replied “Yes” to the question, then he/she was probed and asked to list the types and support giving bodies as much as possible. Finally, we reviewed each patient’s medical record to get further information on disease history, medical conditions, treatment modality, and other relevant biomedical data.

Data Management and Quality Control

The questionnaire and checklist were developed based on the available literature and contextualized by considering the local contexts; double-blind translated and pre-tested. We recruited the research team and trained them on data collection procedures, tools, ethical considerations, and how to obtain informed consent. Additionally, strictly supervising, checking for consistency and completeness, and correcting the errors on-site or before starting the next day’s data collection were carefully followed throughout the fieldwork. Data cleaning was done and we applied robust statistical software and methods.

Study Variables

Dependent Variable

Social support magnitude, types, and its role on diabetes management.

Independent Variables

Socio-demographic, clinical, behavioral, and all other variables, except the dependent variables, indicated in this study were treated as independent variables.

Operational Definitions of Terms

Social support was defined as any type of material (quantifiable aids, financial, instrumental … etc.), and/or non-material (unquantifiable, emotional, psychological … etc.) supports given to the diabetic patients because he/she was a diabetic, from any social support-giving bodies as mentioned by each patient.

Social support-giving bodies include: the public sector, offices, diabetic patients’ associations, family members, friends, colleagues, and other community institutions such as churches and mosques.

The glycaemic level was calculated by getting the last three consecutive scheduled visits’ fasting blood glucose (FBG) mean values and considered as “Controlled” if the mean FBG value was ≤130 mg/dL.

Good adherence to routine follow-up: if the patient attended on average ≥80% of the scheduled follow-ups during the last six months and vis-a-versa.

Data Analysis

Data entry was done in Epi-info version 3.5.1 and then exported into, cleaned, and analyzed in SPSS version 21.0. Descriptive statistics were calculated for all variables, and then bivariable analyses were done by applying the chi-square test and binary logistic regression to explore any association between each independent variable and the outcome variable. Finally, all variables with a P-value ≤0.05 on bivariate analyses were selected and analyzed in the logistic regression model to ascertain the most significant determinants of the dependent variable while simultaneously adjusting for potential confounding factors at a P-value of ≤0.05.


Socio-Demographic Characteristics of Study Participants

A total of 634 adult diabetics were recruited as participants in this study, but 596 of them (40.3% females and 59.7% males) completed the study. Eighty-four percent of the patients were in the age category of 18–60 years, and the patients’ mean age was 45±14.65 years. The vast majority of the study population 419 (70.30%), were protestant Christians, and the rest: 84 (14.10%), 42 (7.10%), 40 (6.70%), and 11 (1.90%) were Orthodox, Catholic, Muslim, and other religions, respectively. More than two-thirds (68.80%) of the study participants earn less than two US dollars per day, and nearly 15% of the patients were economically very dependent on families and/or significant others, and 51.85% of the study population has Radio or Television at his/her home. Still, 100% out-of-pocket spending for medical care was 51.20% in the study area (Table 1).

Table 1 Socio-Demographic Characteristics of Diabetic Patients in Southern Ethiopia, 2020

Health Status and Lifestyles Practices

About 128 (21.50%) of the study participants were type I diabetics, and the remaining 468 (78.50%) were type II DM patients; type I DM was more prevalent among rural patients but type II diabetes was more common among patients from urban settings. Eighty-four percent of the study participants lived for less than ten years with diabetes, and only 66 (11.10%) of the patients had ever participated in programmed diabetes education. Based on the national diabetes management protocol, 385 (64.6%) study participants were eligible for statins preventive treatments but, only 36.10% of them received it. Moreover, 289 (48.49%) study participants confirmed that they knew the availability of senior clinicians like internists in their respective health-care facilities, but unless they had emergency medical conditions, they never got an opportunity to consult the seniors during the last 12 months.

Concerning the risky lifestyle practices of the patients: before they knew their DM status, 98 (16.44%), 203 (34.10%), and 97 (16.28%) of them were tobacco users, alcohol consumers, and Khat, a green leaf plant which contains Cathinone and associated with multiple health risks like causing damage to the endocrine system,24 chewers, respectively; however, once they knew their status and got help from others 6.30% of the tobacco users, 24% of alcohol consumers and 9.20% of the Khat chewers dropped these practices. In contrast, no patient has reported that s/he had started practicing any of these risky behaviors after he/she was diagnosed with diabetes. Even so, Our study result on the patients’ lifestyle modification practices indicated that 242 (40.60%), 393 (65.94%), and 130 (21.81%) of the patients did not follow healthy meal plans, did not do regular physical exercises, and sometimes stop taking treatment when they feel healthy, respectively, and 217 (36.41%) of the patients self-rated their general health status as poor. Additionally, though 87 (14.60%) of the patients own functional glucometer, only 32 (36.78%) were regularly monitoring their blood glucose levels. Furthermore, the magnitude of uncontrolled blood glucose level, comorbidity, acute and chronic diabetic complications were 51.19%, 54.87%, 63.26%, and 51.34% in that order (Table 1).

Social Support

The magnitude of social support for diabetic patients in southern Ethiopia was 50.20% (95% CI: 46.31%, 54.09%), and mainly it has been received from families and close relatives or friends than from formal institutions. For instance, 149 (25%) of the diabetic patients reported that they were members of the Ethiopian diabetic patients’ Association (EDPA), yet, only 93 (15.60%) of them get any support from the EDPA, and only 60 (10.07%) of the patients stated that they sometimes receive some supports from the public sector.

Concerning the support types, our study result showed that non-material support was more prevalent than objective or material support: 263 (44.13%) versus 204 (34.23%), respectively. The support type matrix is presented in Table 2.

Table 2 Tabular Presentation of Social Support Types for Diabetics’ in Southern Ethiopia, 2020

The role of social support on diabetes management was assessed by comparing and contrasting the “yes” answer against the “no” to the question on bivariate and multivariate analyses. Adjusted odds ratio (AOR), P-values, and 95% CI were considered to determine their associations. For instance, even if it was not plausible on multivariable analysis, the odds of getting social support increased by 10% as the educational attainment advanced. It might be confounded with something that was not taken into consideration (Table 3). However, among the variables that showed association during the bivariable analyses model: Residence, occupation, presence of diabetic families, presence of any non-diabetic acute medical condition, blood glucose level, medical follow-up compliance, treatment adherence, and taking the anti-diabetes medicines yesterday became independent predictors of social support on multivariable analysis (Table 4).

Table 3 Factors Associated with Social Support for Diabetic Patients in Southern Ethiopia, 2020

Table 4 Determinants of Social Support for Diabetic Patients in Southern Ethiopia, 2020


In this study, one of every two adult diabetic patients in southern Ethiopia receives any kind of social support when s/he needs it. This figure is comparable to prior study findings from Ethiopia, where the magnitude of social support for diabetics’ ranged from 43.10% to 63.50%25–27 and a study finding from Malaysia, where 51.30% of diabetic patients received it.20 In contrast, the current study finding opposes some other study reports from Ethiopia.28–31 The reasons for the discrepancies might be that, unlike the other surveys, this study assessed the magnitude of social support as its primary objective; involved a higher number of participants, and included patients from all the three hierarchies of the healthcare system.

Studies done elsewhere indicated that social support for diabetics’ is one of the vital interventions to achieve the desirable DM management goals; it helps patients to maintain optimal glycemic level, adhere to lifestyle modifications, increases productivity, improves health, and which, in turn, improves the quality of life of the patients.7,10,32 The result from our study also confirmed that the odds of having blood glucose level controlled, good treatment adherence, and taking the prescribed regimen a day before the current visit to health facility were each three times higher for patients who had received social support than those who did not and the odds of medical follow-up adherence was five times higher for patients who obtained social supports than those who did not get.

Similarly, the odds of getting social support for those patients from diabetic families and patients who had acute non-diabetic medical conditions were twice more than their counterparts. Therefore, it is crucial to strengthen social support for diabetic patients, which, in turn, will help to achieve the desired diabetes management goals.

On the other hand, the current study result indicated that a significantly higher proportion of social support for diabetic patients was given by patients’ families, friends, or significant others than formal organizations, institutions, or public sectors. Furthermore, the types of social support given by these main actors significantly vary too. Thus, it looks like social support for diabetics’ was almost left to patients’ families and/or friends.

Our study finding showed that the odds of getting social support was roughly two times higher for patients from rural areas than those who were from urban settings; and even if it was not statistically plausible in our study, other studies demonstrated that social support positively influences self-management practices among males than females.33

With regard to the study participants’ occupations, employed (those people who are hired and getting monthly salaries from their employer like public or nonpublic sector) were less likely to receive any social support than those patients in the “others” category, which included students, jobless, and patients with disabilities. The higher odds of social support for other occupations may be associated with the fact that one-fifth of our study participants were economically very dependent on others and did not have any considerable incomes. Therefore, they might have looked for more support than the employed ones. Besides, in this study, the patients in the “other” categories were less educated than those employed; thus, they may be more aware of and hunted for social support.

According to our study, 21.31% of the study subjects confirmed the presence of at least one another diabetic family member. This result did agree with prior survey findings from Ethiopia31,34 but, it was inconsistent with others’ findings.27,29 Additionally, the current study indicated that being from a diabetic family has increased the odds of receiving social support by two folds as compared to their counterparts. It might be related to becoming more familiar with diabetes and its care among people with diabetic family members and, this, in turn, might have improved the social support-seeking behaviors.

This study finding established that receiving any social support reduces absenteeism to diabetes management follow-ups by more than five times than those patients who did not get when they needed it. This finding supports other study findings from Malaysia20 and Iran21 where social support was positively associated with and improves medication adherence. Other existing studies also indicated that social support positively influences the patients’ behaviors to manage and engage in healthy recommendations.23

Additionally, our study demonstrated that the odds of treatment adherence was nearly three times higher among patients who were getting social support than those who did not. This result is in line with previous study findings that showed a positive association between social support35 and, also, this study result substantiates a meta-analysis result done by DiMatteo MR that determined social support to diabetics’ increases the likelihood of medication adherence by nearly two folds.36 Furthermore, the current study revealed that taking anti-glycemic drugs a day before the current interview date was positively associated with getting any social support. This is one more point that indicates any social support for diabetic patients plays a significant role in attaining desirable diabetes management goals.

The odd of having blood glucose levels controlled in our study was 2.7 times more likely among diabetic patients who received any support than patients who did not get it. This finding agrees with study findings from China37 and the United States of America23,38 where maintaining optimum glycemic level was associated with the availability of social support, and a narrative review from Iran also acknowledged that social support has a positive effect on glycemic level controlling among Iranian diabetics.32

Our study finding revealed that the odds of receiving any supports was 1.7 times higher among patients who had suffered from non-diabetic acute medical conditions than their healthier diabetic counterparts. It might be related to patients’ higher perception, seeking and receiving the support they need when they encounter additional health issues.


In southern Ethiopia, one of every two adult diabetic patients received any social support when she/he needed it. And residence, some occupations, the presence of a diabetic family member, non-diabetic medical conditions, adherence to medical follow-ups, treatment adherence, having glycemic level controlled, and taking anti-diabetic drugs a day before the current visit to health-care facility were statistically significantly associated with social support.

Given that blood glucose level controlling and keeping good health status are multifaceted and determined by many internal and external factors, social support for diabetic patients plays a crucial role in minimizing and/or averting diabetic complications and other health and related impacts that may occur from poor diabetes management. Therefore, social support for diabetic patients is a fundamental intervention to improve their health and achieve desirable diabetes management goals.

Here we, in our strongest terms, recommend to Ethiopia’s public healthcare system, governmental and non-governmental institutions or organizations, and other stakeholders to join hands to reach the diabetic patients through social support, which, in turn, contributes to achieving the set sustainable development goals of reducing the non-communicable diseases related mortality rates by 2030.

Strengths and Limitations of the Study

This study exclusively depended on oral reports from the social support receivers that might have missed some data from the supply side (providers’ side). And there might be social desirability biases and the cross-sectional nature of the study. However, we did our best to minimize the limitations. Apart from the limitations, this study was the first of its kind to be conducted on social support among diabetic patients in Ethiopia by recruiting patients from all the three-tiered health-care levels and applied a contextualized approach and robust statistical methods.

Data Sharing Statement

The data used to support the findings of this study are all included within the article, but whenever additional information or data is required, the corresponding author will provide it upon reasonable request.

Ethical Considerations

This study was conducted in accordance with the declaration of Helsinki. Tehran University of medical sciences institutional review board (TUMS-IRB) approved the study with a reference number IR.TUMS.SPH.REC.1398.078, and then the SNNPRS health bureau also approved the study, and each patient gave informed written consent to participate in the study.


We would like to acknowledge all the study participants, data collectors, data clerks, and supervisors without their active participation and commitments accomplishing the whole work would have been impossible. Our heartfelt gratitude goes to Tehran University of Medical Sciences (TUMS) and TUMS international campus (TUMS-IC) for giving this golden Ph.D. opportunity to TTH.

Author Contributions

TTH and EJP contributed in the conception, study design, execution, acquisition of data, analysis, interpretation, and have written the article; DGA has contributed in data acquisition, analysis, interpretation and substantially revised the article, and AMM and ARF contributed in the conception, study design and critically reviewed the article. All authors gave final approval of the version to be published; have agreed on the journal to which the article has been submitted, and agree to be accountable for all aspects of the work.


Tehran University of medical sciences partly funded this study, and the associated grant number was not applicable; however, the funder never had involved from the conception of the study through the decision to publish. Thus, we confirmed that there was no conflict of interest from the funder.


The authors report no conflicts of interest for this work.


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