Back to Browse Journals » Biologics: Targets and Therapy » Volume 2 » Issue 4

The insulin-like growth factor system and its receptors: A potential novel anticancer target

Authors Colin R. Lindsay, T R Jeffry Evans

Published 5 December 2008 Volume 2008:2(4) Pages 855—864


Review by Single-blind

Peer reviewer comments 3

Colin R. Lindsay1, T R Jeffry Evans1,2

1Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom; 2University of Glasgow, CR-UK Beatson Laboratories, Garscube Estate, Glasgow, United Kingdom

Abstract: The current generation of novel anticancer therapies that are in preclinical and clinical development are based on exploiting our increasing understanding of the molecular and cellular basis of cancer development and progression. Accelerated rates of cell division and proliferation have been postulated to predispose to the development of malignant disease. The insulin-like growth factor (IGF) signaling system has an important physiological role in regulating cellular proliferation and apoptosis. This function has led to considerable interest in its relevance to neoplasia over the last decade. In this review, we give an overview of the IGF system physiology, discuss the epidemiological significance of IGF signaling and neoplasia, and review the preclinical and clinical studies in targeting IGF receptors as cancer therapies.

Keywords: insulin, growth factor, IGF-1, clinical trials

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Construction and characterization of an anti-CD20 mAb nanocomb with exceptionally excellent lymphoma-suppressing activity

Li H, Wu C, Chen T, Zhang G, Zhao H, Ke C, Xu Z,

International Journal of Nanomedicine 2015, 10:4783-4796

Published Date: 30 July 2015

Using professional interpreters in undergraduate medical consultation skills teaching

Bansal A, Swann J, Smithson WH

Advances in Medical Education and Practice 2014, 5:439-450

Published Date: 21 November 2014

Community engagement in US and Canadian medical schools

Adam O Goldstein, Rachel Sobel Bearman

Advances in Medical Education and Practice 2011, 2:43-49

Published Date: 25 January 2011

Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent

Peter Reimer, Rolf Vosshenrich

Biologics: Targets and Therapy 2010, 4:199-212

Published Date: 4 August 2010

A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis

Stephen P Myers, Joan O’Connor, J Helen Fitton, et al.

Biologics: Targets and Therapy 2010, 4:33-44

Published Date: 12 February 2010

Top-down or bottom-up: Contrasting perspectives on psychiatric diagnoses

Willem MA Verhoeven, Siegfried Tuinier, Ineke van der Burgt

Biologics: Targets and Therapy 2008, 2:409-417

Published Date: 12 September 2008