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The influences of bariatric surgery on hemoglobin A1c in a sample of obese patients in Saudi Arabia

Authors Ahmed AE, Alanazi WR, Ahmed RA, AlJohi W, AlBuraikan DA, AlRasheed BA, ALMuqbil BI, Al-Zahrani AA, Yousef ZM, AL-Jahdali H

Received 4 January 2018

Accepted for publication 23 March 2018

Published 12 June 2018 Volume 2018:11 Pages 271—276

DOI https://doi.org/10.2147/DMSO.S161540

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou

Anwar E Ahmed,1,2 Wala R Alanazi,3 Rayan A Ahmed,4 Wijdan AlJohi,2 Doaa A AlBuraikan,2 Budor A AlRasheed,2 Bashayr I ALMuqbil,2 Ali A Al-Zahrani,2,5 Zeyad M Yousef,2,5 Hamdan AL-Jahdali2,5

1King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia; 2King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 3Al-Maarefa College for Science and Technology, Riyadh, Saudi Arabia; 4Dar Al Uloom University, Riyadh, Saudi Arabia; 5King Abdulaziz Medical City, Riyadh, National Guard Health Affairs, Riyadh, Saudi Arabia

Background: Although the frequency of surgical weight loss interventions has increased in Saudi Arabia, literature describing the clinical outcomes of bariatric surgery in Saudi Arabia is limited. This study aimed to assess whether weight loss intervention improves hemoglobin A1c (HbA1c) in obese patients and to identify its associated factors.
Patients and methods: A retrospective study was carried out on 318 patients with obesity class 1 or higher (body mass index [BMI] ≥ 30 kg/m2) who underwent laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass at King Abdulaziz Medical City in Riyadh, Saudi Arabia, between January 1, 2001 and March 31, 2017. Preoperatively and 12 months postoperatively, characteristics of patients were collected. BMI reduction was calculated, based on which patients were divided into three groups (0–9, 10–14, and >14 kg/m2).
Results: The postoperative HbA1c was 5.83±0.9, while the baseline level was 6.74±2.1 (P=0.001). Fifty-eight of the 318 patients had diabetes. We observed significantly higher HbA1c in diabetic than in non-diabetic patients preoperatively, whereas an insignificantly ­different HbA1c was observed postoperatively. Among those who had minimal reduction in BMI (0–9 kg/m2), we observed significantly higher HbA1c in diabetic than in non-diabetic patients, whereas among those who had large reduction in BMI (10–14 kg/m2) and (>14 kg/m2), we observed insignificant differences in HbA1c in diabetic than in non-diabetic patients.
Conclusion: Being a diabetic patient was related to a significant reduction in HbA1c levels postoperatively. The study suggests that the reduction in HbA1c levels could be modified by BMI, wherein greater reduction in BMI leads to greater reduction in HbA1c levels.

Keywords: HbA1c, diabetes, weight loss surgery, BMI, morbid obese, sleeve

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