Back to Journals » The Application of Clinical Genetics » Volume 6

The genetics of multiple sclerosis: review of current and emerging candidates

Authors Muñoz-Culla M, Irizar H, Otaegui D

Received 19 February 2013

Accepted for publication 5 April 2013

Published 8 August 2013 Volume 2013:6 Pages 63—73

DOI https://doi.org/10.2147/TACG.S29107

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Maider Muñoz-Culla,1,2 Haritz Irizar,1,2 David Otaegui1,2

1Multiple Sclerosis Unit, Instituto Biodonostia, San Sebastián, Spain; 2Red Española de Esclerosis Múltiple (REEM), Barcelona, Spain

Abstract: Multiple sclerosis (MS) is a complex disease in which environmental, genetic, and epigenetic factors determine the risk of developing the disease. The human leukocyte antigen region is the strongest susceptibility locus linked to MS, but it does not explain the whole heritability of the disease. To find other non-human leukocyte antigen loci associated with the disease, high-throughput genotyping, sequencing, and gene-expression studies have been performed, producing a valuable quantity of information. An overview of the genomic and expression studies is provided in this review, as well as microRNA-expression studies, highlighting the importance of combining all the layers of information in order to elucidate the causes or pathological mechanisms occurring in the disease. Genetics in MS is a promising field that is presumably going to be very productive in the next decade understanding the cross talk between all the factors contributing to the development of MS.

Keywords: multiple sclerosis, genetics, gene expression, microRNA

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]