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The genetics of Ménière’s disease

Authors Chiarella G, Petrolo C, Cassandro E

Received 5 October 2014

Accepted for publication 25 November 2014

Published 8 January 2015 Volume 2015:8 Pages 9—17

DOI https://doi.org/10.2147/TACG.S59024

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Martin H. Maurer


Giuseppe Chiarella,1 C Petrolo,1 E Cassandro2

1Department of Experimental and Clinical Medicine, Audiology and Phoniatrics Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy; 2Department of Medicine and Surgery, University of Salerno, Salerno, Italy

Abstract: Our understanding of the genetic basis of Ménière’s disease (MD) is still limited. Although the familial clustering and the geographical and racial differences in incidence strongly suggest a certain role for genetic factors in the development of MD, no convincing evidence for an association with any gene exists, at present. In this review, starting from rational bases for a genetic approach to MD, we explored the numerous reports published in literature and summarize the recent advances in understanding of the genetic fundaments of the disease.

Keywords: Mènière’s disease, gene, vertigo, etiology, pathogenesis

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