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The Exosome And Breast Cancer Cell Plasticity

Authors Mao X, Jin F

Received 26 June 2019

Accepted for publication 5 October 2019

Published 18 November 2019 Volume 2019:12 Pages 9817—9825

DOI https://doi.org/10.2147/OTT.S214133

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Sanjeev Srivastava


Xiaoyun Mao, Feng Jin

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China

Correspondence: Feng Jin
Department of Breast Surgery, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang City, Liaoning Province, People’s Republic of China
Tel/Fax +86 24 83282618
Email jinfeng66cn@hotmail.com

Abstract: Cancer cell plasticity is the ability of cancer cells to reversibly interchange between distinct cell status, which plays a key role in cancer progression. Cancer cell plasticity is now known to be shaped by the secreted nanoparticles termed exosomes which transport proteins and lipids as well as nucleic acids. These aspects have emerged as key determinants of tumor progression and targeting, with approaches such as immunotherapy showing promise in the clinic. While significant strides have been made in this research area, some very interesting questions still warrant more and deeper investigation. We provide a review of the interplay between exosomes and breast cancer cell plasticity, and the potential implication in metastases and drug-resistance.

Keywords: exosome, breast cancer, cancer cell plasticity

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