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The Emerging Roles of miR-125b in Cancers

Authors Wang Y, Zeng G, Jiang Y

Received 25 September 2019

Accepted for publication 2 February 2020

Published 12 February 2020 Volume 2020:12 Pages 1079—1088

DOI https://doi.org/10.2147/CMAR.S232388

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Sanjeev Srivastava


Ying Wang,1 Guilin Zeng,1 Yicheng Jiang2

1Department of Oncology, The Fifth People’s Hospital of Chengdu, Chengdu, People’s Republic of China; 2Department of Oncology, The People’s Hospital of Chongqing Hechuan, Chongqing, People’s Republic of China

Correspondence: Ying Wang
Department of Oncology, The Fifth People’s Hospital of Chengdu, Chengdu, People’s Republic of China
Email wangying_onco@163.com

Abstract: MicroRNAs (miRNAs) are endogenous, noncoding, single-stranded RNA molecules of 22 nucleotides in length. MiRNAs have both tumor-suppressive properties and oncogenic properties that can control critical processes in tumors. Mature miR-125b originates from miR-125b-1 and miR-125b-2 and leads to the degradation of target mRNAs or the inhibition of translation through binding to the 3′ untranslated regions (3′-UTR) of target mRNAs. Importantly, miR-125b is involved in regulating NF-κB, p53, PI3K/Akt/mTOR, ErbB2, Wnt, and another signaling pathways, thereby controlling cell proliferation, differentiation, metabolism, apoptosis, drug resistance and tumor immunity. This review aims to summarize the recent literature on the role of miR-125b in the regulation of tumorigenesis and to explore its potential clinical application in the diagnosis, prognosis and clinical treatment of tumors.

Keywords: miR-125b, cancer, biomarker, pathway

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