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The Efficacy, Safety and Tolerability of Canakinumab in the Treatment of Familial Mediterranean Fever: A Systematic Review of the Literature

Authors Kacar M, Savic S, van der Hilst JCH

Received 14 January 2020

Accepted for publication 20 February 2020

Published 9 March 2020 Volume 2020:13 Pages 141—149

DOI https://doi.org/10.2147/JIR.S206204

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Ning Quan


Mark Kacar,1 Sinisa Savic,1 Jeroen CH van der Hilst2,3

1Department of Clinical Immunology and Allergy, St James´s University Hospital, Leeds, UK; 2Department of Infectious Diseases and Immunity, Jessa Hospital, Hasselt, Belgium; 3BIOMED Research Institute, University of Hasselt, Hasselt, Belgium

Correspondence: Jeroen CH van der Hilst
Department of Infectious Diseases and Immunity, Jessa Hospital, Stadsomvaart 11, Hasselt 3500, Belgium
Tel +32 11309485
Email jeroen.vanderhilst@jessazh.be

Abstract: Familial Mediterranean Fever (FMF) is the most prevalent genetic autoinflammatory disorder. In most patients, treatment with colchicine can prevent attacks of fever and inflammation. However, 5%– 10% of patients are resistant to colchicine treatment, while a similar percentage cannot tolerate colchicine in doses needed to prevent attacks. For these patients, Canakinumab, a full human antibody against IL-1β, has been approved recently by the FDA and EMA. In this article, we present a systematic review of the long-term efficacy, safety, and tolerability of Canakinumab in FMF patients who cannot tolerate colchicine or who are resistant to colchicine treatment.

Keywords: familial mediterranean fever, Canakinumab, anti-IL1 therapy

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