Back to Journals » Infection and Drug Resistance » Volume 5

The effects of daily chlorhexidine bathing on cutaneous bacterial isolates: a pilot study

Authors Soma V, Qin, Zhou, Adler, Berry, Zerr

Received 8 February 2012

Accepted for publication 28 February 2012

Published 24 April 2012 Volume 2012:5 Pages 75—78


Review by Single-blind

Peer reviewer comments 2

Vijaya L Soma1, Xuan Qin2, Chuan Zhou1, Amanda Adler1, Jessica E Berry2, Danielle M Zerr1
1Department of Pediatrics, 2Department of Laboratory Medicine, University of Washington, Seattle, WA, USA

Abstract: Chlorhexidine gluconate (CHG) is a topical antiseptic used in a myriad of clinical settings. Recently, CHG baths have been shown to decrease multidrug-resistant organism acquisition and infections and catheter-associated bloodstream infections. The present study examined the effects of daily bathing with CHG on the recovery and antimicrobial susceptibility of cultivable cutaneous bacteria. The objectives of this study were to (1) explore the effects of clinical CHG bathing on cultivable cutaneous bacteria, (2) study the relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility of coagulase-negative staphylococci, and (3) demonstrate the feasibility of the approach so a more definitive study may be performed. Significant decreases in bacterial colony counts and phenotypic diversity occurred with greater CHG exposure. The findings also suggest an inverse relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility. Larger prospective studies are necessary to fully investigate the clinical impact of CHG usage.

Keywords: antiseptic, resistance, Staphylococcus, coagulase-negative

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]