The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
Authors Paulose JK, Wang C, O'Hara BF, Cassone VM
Received 4 May 2019
Accepted for publication 24 June 2019
Published 12 August 2019 Volume 2019:11 Pages 113—121
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Sutapa Mukherjee
Jiffin K Paulose,1 Chanung Wang,1,2 Bruce F O’Hara,1 Vincent M Cassone1
1Department of Biology, University of Kentucky, Lexington, KY 40515, USA; 2Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
Background: Sleep disturbances are common maladies associated with human age. Sleep duration is decreased, sleep fragmentation is increased, and the timing of sleep onset and sleep offset is earlier. These disturbances have been associated with several neurodegenerative diseases. Mouse models for human sleep disturbances can be powerful due to the accessibility to neuroscientific and genetic approaches, but these are hampered by the fact that most mouse models employed in sleep research have spontaneous mutations in the biosynthetic pathway(s) regulating the rhythmic production of the pineal hormone melatonin, which has been implicated in human sleep.
Purpose and method: The present study employed a non-invasive piezoelectric measure of sleep wake cycles in young, middle-aged and old CBA mice, a strain capable of melatonin biosynthesis, to investigate naturally-occurring changes in sleep and circadian parameters as the result of aging.
Results: The results indicate that young mice sleep less than do middle-aged or aged mice, especially during the night, while the timing of activity onset and acrophase is delayed in aged mice compared to younger mice.
Conclusion: These data point to an effect of aging on the quality and timing of sleep in these mice but also that there are fundamental differences between control of sleep in humans and in laboratory mice.
Keywords: sleep, circadian rhythms, aging, piezoelectric, CBA/J
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