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The Effect of Serum Ferritin Level on Gonadal, Prolactin, Thyroid Hormones, and Thyroid Stimulating Hormone in Adult Males with Sickle Cell Anemia

Authors Mostafa GG, Zahran FE, Omer SA, Ibrahim A, Elhakeem H

Received 4 October 2019

Accepted for publication 15 January 2020

Published 28 January 2020 Volume 2020:11 Pages 27—32

DOI https://doi.org/10.2147/JBM.S232562

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth


Gamal G Mostafa,1 Fawkia E Zahran,2,3 Sawsan A Omer,3,4 Ahmed Ibrahim,5 Heba Elhakeem6

1Department of Clinical Adult Hematology, Faculty of Medicine, Aswan University, Aswan, Egypt; Haematology, Hereditary Blood Disease Centre- Hofuf, Hofuf, Kingdom of Saudi Arabia; 2Department of Internal Medicine, Faculty of Medicine for Girls, Al- Azhar University, Cairo, Egypt; 3King Fahad Hospital, Hofuf, Al Hofuf, Kingdom of Saudi Arabia; 4Department of Internal Medicine, Faculty of Medicine, University of Gezira, Wad Madani, Sudan; 5Department of Community Medicine, Faculty of Medicine, University of Western Kordofan, Al-Foula, Sudan; Prince Sultan Cardiac Center, Al Hassa, Al Hasa, Kingdom of Saudi Arabia; 6Clinical Pathology Department, Faculty of Medicine for Girls, Alazhar University, Cairo, Egypt

Correspondence: Sawsan A Omer
King Fahad Hospital, Hofuf, Eastern Region, Kingdom of Saudi Arabia
Tel +966 553210343
Email sawsanomer63@yahoo.co.uk

Background: Sickle cell anaemia (SCA) is an inherited hemoglobinopathy resulting in sickling of erythrocytes that cause micro-vascular obstruction leading to acute complications and chronic organ damage. Adults with SCA have endocrine complications and metabolic alterations. The aim of this study was to assess the association between gonadal and thyroid hormones with iron indices and to explore the potential association between serum ferritin levels and sex hormones in adult males with sickle cell disease in New Prince Saud Bin Jalawy Hospital (NPSBJH) in Hofuf city (Eastern region of Saudi Arabia) where there are many patients with SCA.
Methods: A cross-sectional analytical study was carried out in the Haematology Clinic at NPSBJH in 2018. A total of eighty (80) male patients with sickle cell anaemia were included in this study and were divided into two groups according to serum ferritin level. Group I (G-I): Included 40 male patients with high serum ferritin level and group II (G-II): included 40 male patients with normal serum ferritin level.
Results: There was a significant difference in height/cm between GI and Gil, P value= 0.006. Serum ferritin was significantly higher in GI (P value= 0.000), and serum TIBC was significantly higher in G-II. (P value= 0.022). Testosterone level was significantly higher in G-II (P value= 0.018). Luteinizing hormone (LH) was significantly higher in group I (P-value 0.019). There was a significant relation between serum ferritin level in G-I and the following: serum iron, TIBC, serum testosterone, LH, prolactin, free T3 and free T4.
Conclusion: Adult males with SCD with high serum ferritin level were shorter than adult males with SCD who had normal serum ferritin level and had a significant lower level of serum testosterone and significant high level of LH and this was most likely due to endocrine dysfunction secondary to high ferritin level and iron overload.

Keywords: sickle cell disease, ferritin, testosterone, prolactin


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