Back to Journals » Drug Design, Development and Therapy » Volume 7

The effect of prostaglandin analogs on the biomechanical properties and central thickness of the cornea of patients with open-angle glaucoma: a 3-year study on 108 eyes

Authors Tsikripis P, Papaconstantinou D, Koutsandrea C, Apostolopoulos M, Georgalas I

Received 27 June 2013

Accepted for publication 21 August 2013

Published 4 October 2013 Volume 2013:7 Pages 1149—1156


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Panagiotis Tsikripis, Dimitrios Papaconstantinou, Chryssanthi Koutsandrea, Michalis Apostolopoulos, Ilias Georgalas

Department of Ophthalmology, University of Athens, Athens, Greece

Purpose: To evaluate the effect of prostaglandin analogs (PGAs) on the biomechanical properties (corneal hysteresis [CH], corneal resistance factor [CRF]) and central corneal thickness (CCT) of patients with open-angle glaucoma.
Methods: A total of 108 eyes were prospectively included for repeated measurements of intraocular pressure (IOP) with Goldmann applanation tonometry (GAT) and ocular response analyzer (ORA), CCT, followed by CH and CRF measurements by the ORA, during the same visit. Of these, 66 were treated with latanoprost, and 42 were treated with latanoprost and timolol. IOP, CH, CRF, and CCT were measured before treatment and at 6-month intervals.
Results: It appears that under local PGA treatment, IOP values decreased and CH and CCT significantly increased, whereas CRF did not. CCT slightly but significantly increased at all time points of the study (0.50–3.00 µm and 1.50–5.50 µm), and we observed a constant significant increase in CH (0.4–0.7 mmHg and 0.65–0.95 mmHg). Concerning the correlation of GAT IOP with CCT and CH, it was found that at the time points 0, 1, and 2 there were statistically significant correlations.
Conclusion: The changes of CCT and CH under PGA treatment in clinical practice may influence IOP measurements and patient follow-up significantly. This should be investigated further to confirm the relationship between corneal properties and treatment of open-angle glaucoma.

Keywords: corneal hysteresis, corneal resistance factor, central corneal thickness, glaucoma, prostaglandins, ocular response analyzer, intraocular pressure

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]