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The effect of Helicobacter pylori on asthma and allergy

Authors Amedei A, Codolo G, Del Prete G, de Bernard M, D'Elios MM

Published 29 September 2010 Volume 2010:3 Pages 139—147


Review by Single anonymous peer review

Peer reviewer comments 2

Amedeo Amedei1, Gaia Codolo2, Gianfranco Del Prete1, Marina de Bernard2, Mario M D’Elios1
1Policlinico AOU Careggi, Department Internal Medicine, University of Florence, Italy; 2Venetian Institute of Molecular Medicine, University of Padua, Italy

Abstract: Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy.

Keywords: Helicobacter pylori neutrophil-activating factor, protein, Th-1/Th-2, Treg, asthma

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