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The effect of evening primrose oil on fatigue and quality of life in patients with multiple sclerosis

Authors Majdinasab N, Namjoyan F, Taghizadeh M, Saki H

Received 17 August 2017

Accepted for publication 6 April 2018

Published 12 June 2018 Volume 2018:14 Pages 1505—1512


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Video abstract presented by Hamid Saki

Views: 1992

Nastaran Majdinasab,1 Foroogh Namjoyan,2 Mohsen Taghizadeh,3 Hamid Saki4

1Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Musculoskeletal Rehabilitation Research Center, Ahvaz, Iran; 2Department of Pharmacognosy, Marine Natural Pharmaceutical Research Center, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Department of Nutrition, Research Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran; 4Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Background: Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system that is characterized by demyelination in the central nervous system. In regard to the prevalence of diseases and enormous costs imposed on society and the health system, finding a way to stop the progression of the disease using drugs with fewer side effects seems a serious sanitation issue to the health of the international community. This study aimed to evaluate the effect of evening primrose oil (EPO) on fatigue and quality of life in patients with MS.
Materials and methods: In this double-blind randomized clinical trial, 52 patients with MS were chosen and categorized into 2 groups which received 2 doses of EPO and placebo. In addition, the quality of life and fatigue scale in these patients were investigated before the treatment and again 3 months after therapy. The findings were then compared between the 2 groups.
Result: EPO consumption significantly increased cognitive function, vitality, and overall life satisfaction and also reduced pain and fatigue compared to placebo (P<0.05).
Conclusion: Our findings indicated that EPO consumption had no impact on the quality of life in general; however, it had a significant effect on several important aspects of life quality such as the increase of cognitive function, vitality, and overall life satisfaction. It also reduced the pain and fatigue in comparison to the placebo consumption. Herbal medicines are brittle and have fewer side effects than chemical drugs. With use of this plant, reduced fatigue and improved quality of life were observed in MS patients. But the drug did not prevent the progression of the disease.

Keywords: cognitive function, vitality, overall life satisfaction, pain, fatigue

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