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The Effect of Admission Serum Magnesium on the Acute Kidney Injury Among Patients with Malignancy

Authors Shen D, Wang Y, Xu J, Li Y, Chen X, Guo M, Geng X, Ding X, Xu X

Received 21 May 2020

Accepted for publication 22 July 2020

Published 11 August 2020 Volume 2020:12 Pages 7199—7207

DOI https://doi.org/10.2147/CMAR.S262674

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Eileen O'Reilly


Daoqi Shen, Yimei Wang, Jiarui Xu, Yang Li, Xiaohong Chen, Man Guo, Xuemei Geng, Xiaoqiang Ding, Xialian Xu

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney Disease and Dialysis (SIKD), Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Medical Center of Kidney Disease, Shanghai, People’s Republic of China

Correspondence: Xiaoqiang Ding; Xialian Xu
Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney Disease and Dialysis (SIKD), Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Medical Center of Kidney Disease, 180 Fenglin Road, Xuhui District, Shanghai, People’s Republic of China
Email ding.xiaoqiang@zs-hospital.sh.cn; xu.xialian@zs-hospital.sh.cn

Purpose: This study aimed to explore the relationship between serum magnesium (Mg) levels and incidence of acute kidney injury (AKI) in patients with malignancy.
Patients and Methods: Hospitalized patients with malignancy between October 1, 2014 and September 30, 2015 in Zhongshan Hospital were recruited. All relevant data were extracted from the electronic database.
Results: All 99,845 patients were enrolled and 16,082 eligible patients were divided into three groups according to admission serum Mg levels in this study. Among them, 2383 (14.8%) cases were diagnosed as AKI. The incidence of AKI showed a V trend with the increase of serum Mg level. The effect of low serum Mg level on the onset of AKI seems to be greater than high serum Mg level. Patients with low serum Mg level spent a longer time in the hospital than those with normal serum Mg level and high serum Mg level. Further, multivariate logistic regression model was used to assess the importance of serum Mg level to influence AKI incidence. There was a higher AKI incidence in patients with magnesium level 0.66mmol/L or less (aOR=2.438, 95% CI=1.696, 3.505).
Conclusion: Low serum Mg level might be a independent risk factor for AKI in patients with malignancy. Appropriate clinical intervention for serum Mg disorder may contribute to decreasing the incidence of AKI and the possibility of poor outcomes in cancer patients.

Keywords: hypomagnesemia, cancer, acute kidney injury, electrolyte disorders

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