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The Effect and Mechanism of Adverse Childhood Experience on Suicide Ideation in Young Cancer Patients During Coronavirus Disease 2019 (COVID-19) Pandemic

Authors Yang G, Xiao C, Li S, Yang N

Received 18 June 2020

Accepted for publication 8 August 2020

Published 24 August 2020 Volume 2020:13 Pages 1293—1300

DOI https://doi.org/10.2147/RMHP.S266269

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Marco Carotenuto


Guoqing Yang1 ,* Chenchang Xiao2 ,* Shiyue Li,3 Ningxi Yang1

1College of Humanities and Social Sciences, Harbin Engineering University, Harbin, People’s Republic of China; 2City College, Wuhan University of Science and Technology, Wuhan, People’s Republic of China; 3School of Health Sciences, Wuhan University, Wuhan, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Ningxi Yang College of Humanities and Social Sciences
Harbin Engineering University, NO. 145 Nantong Road, Harbin, Heilongjiang, People’s Republic of China
Tel +86 45182569608
Email yangningxi@bjmu.edu.cn

Background and Aim: Coronavirus disease 2019 (COVID-19) is currently prevalent worldwide. This research aimed to explore the effect of adverse childhood experience (ACE) on suicide ideation in young cancer patients during the COVID-19 pandemic. Self-reported questionnaires analyzed the mediating effects of sleep quality, anxiety symptoms, and inflammatory conditions between ACE and suicide ideation.
Materials and Methods: A total of 197 young cancer patients (age 18– 40) completed questionnaires and a blood test. Correlation analysis and structural equation model were used to explore the relationships between ACE, sleep quality, anxiety symptom, serum C-reactive protein (CRP) levels and suicide ideation. The mediating roles of sleep quality, anxiety symptoms, and CRP levels on the influence of ACE on suicide ideation were explored.
Results: ACE was positively related to anxiety symptoms, CRP levels, and suicide ideation, and negatively related to sleep quality. Anxiety symptoms and CRP levels were positively related to suicide ideation, while sleep quality was negatively related to suicide ideation. Anxiety symptoms were positively related to CRP levels but negatively related to sleep quality. From these results, we found ACE affected suicide ideation directly and was mediated by roles sleep quality, anxiety symptom and CRP.
Conclusion: ACE not only directly affected suicide ideation but also affected suicide ideation through sleep quality, anxiety symptoms, and inflammatory conditions in young cancer patients during the COVID-19 pandemic. Therefore, targeted intervention and help for cancer patients from the perspective of ACE should be put into practice.

Keywords: coronavirus disease 2019, psychosocial oncology, adverse childhood experience, anxiety symptom, sleep quality, suicide ideation

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