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The diurnal and nocturnal effects of travoprost in normal-tension glaucoma

Authors Seibold LK, Kahook M

Received 23 August 2014

Accepted for publication 22 September 2014

Published 31 October 2014 Volume 2014:8 Pages 2189—2193


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Leonard K Seibold, Malik Y Kahook

Department of Ophthalmology, University of Colorado Eye Center, Aurora, CO, USA

Purpose: To determine the diurnal and nocturnal effects of travoprost with sofZia® (Travatan Z® [TZ]) on intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with normal-tension glaucoma (NTG).
Methods: Twenty-seven subjects with NTG were admitted to an inpatient sleep laboratory for three 24-hour sessions monitoring IOP, blood pressure (BP), and heart rate every 2 hours in the habitual position (diurnal period: upright; nocturnal period: supine). Baseline IOP and OPP levels were compared to those during active treatment with TZ and 3 days after stopping the medication. OPP was calculated as 2/3 [diastolic BP + 1/3 (systolic BP – diastolic BP)] – IOP.
Results: TZ significantly reduced the mean diurnal and nocturnal IOP levels compared to baseline at all time points. During treatment, mean IOP decreased from 17.1±3.4 to 14.7±3.0 mmHg during the diurnal period (P<0.01) and from 19.9±3.6 to 18.8±3.5 mmHg during the nocturnal period (P<0.01). Once treatment was discontinued, mean IOP remained at levels significantly less than baseline during both the diurnal (15.6±3.2 mmHg) and nocturnal (18.7±3.7 mmHg) periods. Mean OPP was not significantly changed with treatment during either period.
Conclusion: In this population of NTG patients, TZ significantly lowers IOP at all time points throughout the diurnal and nocturnal periods. The treatment effect on IOP endures for up to 3 days after the last dose. Treatment did not significantly improve OPP.

Keywords: ocular perfusion pressure, intraocular pressure, 24-hour, diurnal, nocturnal, sofZia®

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