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The digital aqueous humor outflow meter: an alternative tool for screening of the human eye outflow facility

Authors Vassilios P Kozobolis, Eleftherios I Paschalis, Nikitas C Foudoulakis, et al

Published 26 August 2010 Volume 2010:4 Pages 937—945

DOI https://doi.org/10.2147/OPTH.S11967

Review by Single-blind

Peer reviewer comments 3

Vassilios P Kozobolis, Eleftherios I Paschalis, Nikitas C Foudoulakis, Stavrenia C Koukoula, Georgios Labiris

Department of Ophthalmology and Eye Institute of Thrace, Democritus University of Thrace, Alexandroupolis, Greece

Purpose: To develop, characterize, and validate a prototype digital aqueous humor outflow tonographer (DAHOM).

Material and methods: The DAHOM was developed, characterized, and validated in three phases. Phase 1 involved construction of the sensor. This was broadly based on the fundamental design of a typical Schiotz tonographer with a series of improvements, including corneal indentation, which was converted to an electrical signal via a linear variable differential transducer, an analog signal which was converted to digital via ADC circuitry, and digital data acquisition and processing which was made possible by a serial port interface. Phase 2 comprised development of software for automated assessment of the outflow facility. Automated outflow facility assessment incorporated a series of fundamental improvements in comparison with traditional techniques, including software-based filtering of ripple noise and extreme variations, rigidity impact analysis, and evaluation of the impact of patient age, central corneal thickness, and ocular axial length. Phase 3 comprised characterization and validation of DAHOM, for which we developed an experimental setup using porcine cadaver eyes. DAHOM’s repeatability was evaluated by means of Cronbach’s alpha and intraclass correlation coefficient. The level of agreement with a standard Schiotz tonographer was evaluated by means of paired t-tests and Bland-Altman analysis in human eyes.

Results: The experimental setup provided the necessary data for the characterization of DAHOM. A fourth order polynomial equation provided excellent fit (R square >0.999). DAHOM demonstrated high repeatability (Cronbach’s alpha ≥0.997; intraclass correlation coefficient ≥0.987) and an adequate level of agreement with a standard Schiotz tonographer.

Conclusions: This study presents the development, characterization, and validation of a prototype digital tonographer. DAHOM demonstrates high repeatability and a sufficient level of agreement with a typical Schiotz tonographer, while its digital design remedies known vulnerabilities of conventional tonographers.

Keywords: glaucoma, tonography, pressure, outflow facility, aqueous humor

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