The diagnostic accuracy of liquid exosomes for lung cancer detection: a meta-analysis
Authors Song Z, Wang S, Liu Y
Received 26 September 2018
Accepted for publication 4 December 2018
Published 24 December 2018 Volume 2019:12 Pages 181—192
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Sanjeev Srivastava
Zhipeng Song, Saisai Wang, Yang Liu
Department of Epidemiology, Beijing Chest Hospital, Capital Medical University, Beijing, China
Purpose: Several studies have suggested that liquid exosomes can be used as biomarkers for the diagnosis of lung cancer (LC). The purpose of this meta-analysis was to investigate the comprehensive diagnostic value of liquid exosomes for LC.
Materials and methods: Relevant studies were searched from multiple electronic databases. The quality of the studies was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 criteria in RevMan 5.3 software. Stata 14.0 software and Meta-disc 1.4 software were used to synthesize the diagnostic parameters. Publication bias was judged according to the Deeks’ funnel plot asymmetry test.
Results: There were 13 eligible articles that comprised 1,338 LC patients and 1,075 paired controls for the meta-analysis. The pooled sensitivity (SEN), specificity (SPE), diagnostic likelihood ratio positive (DLR+), diagnostic likelihood ratio negative (DLR-), diagnostic OR (DOR), and area under the curve (AUC) of liquid exosomes in diagnosing LC were 0.82 (95% CI: 0.76–0.87), 0.84 (95% CI: 0.77–0.89), 5.27 (95% CI: 3.58–7.75), 0.21 (95% CI: 0.15–0.29), 25.14 (95% CI: 14.25–44.33), and 0.90 (95% CI: 0.87–0.92), respectively. Research based on serum, miRNA, the isolation kit method, one index in exosomes, patient sample size of 50 or greater, and control group size of 50 or greater obtained higher AUC values when the LC type was small cell lung cancer.
Conclusion: Liquid exosomes have shown potential as novel biomarkers that could facilitate LC diagnosis. Further prospective studies are still needed to confirm the diagnostic value of liquid exosomes.
Keywords: lung neoplasm, liquid, exosomes, diagnosis, meta-analysis
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]