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The coexistence of a Wilms’ tumor and renal cell carcinoma in children: a case report and review of the literature

Authors Zou XP, Jiang YY, Liao Y, Dang YW, Chen G, Feng ZB, Ma Y

Received 1 September 2018

Accepted for publication 25 December 2018

Published 30 January 2019 Volume 2019:12 Pages 953—958

DOI https://doi.org/10.2147/OTT.S186102

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Sanjay Singh


Xiao-Ping Zou,1 Yao-Ying Jiang,1 Yan Liao,1 Yi-Wu Dang,1 Gang Chen,1 Zhen-Bo Feng,1 Yun Ma1,2

1Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China; 2Department of Pathology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China

Abstract: A combination of a Wilms’ tumor (WT) and renal cell carcinoma (RCC) is an extremely rare pediatric renal neoplasm. Its prognosis and clinicopathological features remain unclarified. Herein, we describe a case of the coexistence of a WT and an RCC in a male child aged 5 years and 10 months. The child had symptoms of hematuria for more than 1 month. Although his irises were clear, medical imaging revealed a potential malignant tumor in the left kidney. The patient underwent resection of the left kidney. The pathological diagnosis was the coexistence of a WT and papillary RCC. Negative surgical margins were examined. One month following the resection, chemotherapy with vincristine plus dactinomycin (EE-4A regimen) was commenced. At the 69-month follow-up, there was no recurrence or metastasis. The coexistence of a WT and an RCC in the pediatric population is considered a rare pathological event. At present, there is no standard treatment for these renal neoplasms. In this study, the RCC treatment, which was the same as that applied in cases of WTs, was reasonable.

Keywords: papillary renal cell carcinoma, coexistence, renal cell carcinoma, nephroblastoma

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