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The bevacizumab experience in advanced renal cell carcinoma

Authors Harshman L, Srinivas S

Published 15 September 2010 Volume 2010:3 Pages 179—189

DOI https://doi.org/10.2147/OTT.S8157

Review by Single-blind

Peer reviewer comments 3


Lauren C Harshman, Sandy Srinivas
Division of Oncology, Stanford University School of Medicine, Stanford, California, USA

Abstract: Bevacizumab in combination with interferon alfa is now approved for treatment-naïve advanced renal cell carcinoma (RCC) in both the US and Europe. Its objective response rates of 30% and progression-free survival rates of 9–10 months are ­comparable to the other approved first-line multityrosine kinase inhibitors, sunitinib and pazopanib. Its advantages include a different toxicity profile and assurance of ­administration compliance given its intravenous formulation. Enthusiasm for its use is blunted by the increased costs, the potential infusion-related reactions, the associated interferon-related toxicities, and the inconvenience of its nonoral formulation. Further study is warranted to assess its efficacy both as a single agent and in combination with the targeted agents and other immunotherapies. With multiple agents now available for the treatment of advanced RCC, identification of patient and tumor-specific biomarkers to inform our choice of first-line therapy and the proper sequence of subsequent therapies is imperative.

Keywords: bevacizumab, renal cell carcinoma, interferon alfa

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