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The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae

Authors Miossec C, Claudon M, Levasseur P, Black MT

Received 1 September 2013

Accepted for publication 7 October 2013

Published 3 December 2013 Volume 2013:6 Pages 235—240

DOI https://doi.org/10.2147/IDR.S53874

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Christine Miossec, Monique Claudon, Premavathy Levasseur, Michael T Black

Novexel, Romainville, France

Abstract: Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae was investigated by ampC messenger ribonucleic acid quantitation. Cefoxitin and clavulanic acid were confirmed as ampC inducers, whereas avibactam was found to exert no effect on ampC expression. Thus, avibactam is unlikely to diminish the activity of any partner β-lactam antibiotic against AmpC-producing organisms.

Keywords: β-lactamase, ampC, induction, NXL104, avibactam


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