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The Battle of Probiotics and Their Derivatives Against Biofilms

Authors Barzegari A, Kheyrolahzadeh K, Hosseiniyan Khatibi SM, Sharifi S, Memar MY, Zununi Vahed S

Received 4 October 2019

Accepted for publication 6 February 2020

Published 26 February 2020 Volume 2020:13 Pages 659—672

DOI https://doi.org/10.2147/IDR.S232982

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink


Abolfazl Barzegari,1,* Keyvan Kheyrolahzadeh,1,2,* Seyed Mahdi Hosseiniyan Khatibi,3,* Simin Sharifi,4 Mohammad Yousef Memar,5 Sepideh Zununi Vahed3

1Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; 2Azad University, Tabriz, Iran; 3Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 4Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 5Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

*These authors contributed equally to this work

Correspondence: Sepideh Zununi Vahed
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Tel +989140404242
Email sepide.zununi@gmail.com

Abstract: Biofilm-related infections have been a major clinical problem and include chronic infections, device-related infections and malfunction of medical devices. Since biofilms are not fully available for the human immune system and antibiotics, they are difficult to eradicate and control; therefore, imposing a global threat to human health. There have been avenues to tackle biofilms largely based on the disruption of their adhesion and maturation. Nowadays, the use of probiotics and their derivatives has gained a growing interest in battling against pathogenic biofilms. In the present review, we have a close look at probiotics with the ultimate objective of inhibiting biofilm formation and maturation. Overall, insights into the mechanisms by which probiotics and their derivatives can be used in the management of biofilm infections would be warranted.

Keywords: antibiotic resistance, biofilm, probiotics, lactobacillus, sepsis, infection

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