Back to Browse Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 8

The association between COPD and heart failure risk: a review

Authors de Miguel Díez J, Chancafe Morgan J, Jiménez García R

Received 28 February 2013

Accepted for publication 12 April 2013

Published 28 June 2013 Volume 2013:8 Pages 305—312


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Javier de Miguel Díez,1 Jorge Chancafe Morgan,1 Rodrigo Jiménez García2

1Pulmonology Department, Gregorio Maranon University Hospital, Complutense University of Madrid, Madrid, Spain; 2Preventive Medicine and Public Health Teaching and Research Unit, Department of Health Sciences, Rey Juan Carlos University, Madrid, Spain

Abstract: Chronic obstructive pulmonary disease (COPD) is commonly associated with heart failure (HF) in clinical practice since they share the same pathogenic mechanism. Both conditions incur significant morbidity and mortality. Therefore, the prognosis of COPD and HF combined is poorer than for either disease alone. Nevertheless, usually only one of them is diagnosed. An active search for each condition using clinical examination and additional tests including plasma natriuretic peptides, lung function testing, and echocardiography should be obtained. The combination of COPD and HF presents many therapeutic challenges. The beneficial effects of selective ß1-blockers should not be denied in stable patients who have HF and coexisting COPD. Additionally, statins, angiotensin-converting enzyme inhibitors, and angiotensin-receptor blockers may reduce the morbidity and mortality of COPD patients. Moreover, caution is advised with use of inhaled ß2-agonists for the treatment of COPD in patients with HF. Finally, noninvasive ventilation, added to conventional therapy, improves the outcome of patients with acute respiratory failure due to hypercapnic exacerbation of COPD or HF in situations of acute pulmonary edema. The establishment of a combined and integrated approach to managing these comorbidities would seem an appropriate strategy. Additional studies providing new data on the pathogenesis and management of patients with COPD and HF are needed, with the purpose of trying to improve quality of life as well as survival of these patients.

Keywords: chronic obstructive pulmonary disease, heart failure

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] View Full Text [HTML] 


Other article by this author:

Determinants and predictors of the cost of COPD in primary care: A Spanish perspective

Javier de Miguel Diez, Pilar Carrasco Garrido, Marta García Carballo, Angel Gil de Miguel, Javier Rejas Gutierrez, et al

International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:701-712

Published Date: 5 December 2008

Readers of this article also read:

Optical birefringence of liquid crystals for label-free optical biosensing diagnosis

Nguyen TT, Han GR, Jang CH, Ju H

International Journal of Nanomedicine 2015, 10:25-32

Published Date: 25 August 2015

Interactive survey of consumer awareness of nanotechnologies and nanoparticles in consumer products in South Korea

Kim YR, Lee EJ, Park SH, Kwon HJ, An SSA, Son SW, Seo YR, Pie JE, Yoon M, Kim JH, Kim MK

International Journal of Nanomedicine 2014, 9:11-20

Published Date: 15 December 2014

Noninvasive ventilation in acute respiratory failure

Mas A, Masip J

International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:837-852

Published Date: 11 August 2014

A comparison of three multidimensional indices of COPD severity as predictors of future exacerbations

Motegi T, Jones RC, Ishii T, Hattori K, Kusunoki Y, Furutate R, Yamada K, Gemma A, Kida K

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:259-271

Published Date: 31 May 2013

Long-term survival for COPD patients receiving noninvasive ventilation for acute respiratory failure

Titlestad IL, Lassen AT, Vestbo J

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:215-219

Published Date: 26 April 2013